Pyrimidine Nucleotide Synthesis

The skeleton of the pyrimidine nucleotides from:

Aspartate (three carbons and one nitrogen) and the residue is glutamine amide and bicarbonate ion.

Created by CPS II. (carbamoyl phosphate synthetase):

unlike CPS I, it is in the cytosol, it is derived from glutamine and does not regulate N-acetylglutamate.

• It produces carbamoyl phosphate from glutamine, carbon dioxide and 2 ATPs, leaving glutamate.
• An aspartate (aspartate-carbamoyltransferase) is formed, dihydroorotase closes into a ring, and dihydroorotate is formed.
• The only mitochondrial localised enzyme, dihydroorotate dehydrogenase, further forms a flavoprotein.
• An orotate is produced from which a phosphoribosyltransferase OMP (orotidine-5-monophosphate) and a

The skeleton of the pyrimidine nucleotides from:

Created by CPS II. (carbamoyl phosphate synthetase):

The regulation of the synthesis occurs at CPS II:

An essential difference between purine and pyrimidine synthesis:

DNA is generated from

References

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