Purine nucleotides are the adenine or guanine-containing molecules, such as AMP, ADP, ATP, GMP, GDP, GTP.

Figure 1 Purine bases

The sources of the purine base rings

  • one aspartate will give nitrogen,
  • two nitrogen comes from glutamine
  • two carbon and one nitrogen is glycine,
  • two carbons are C1, and one is bicarbonate.
Figure 2. PPP

Synthesis of the purine nucleotides

  1. First, 5-phosphoribosyl-1-pyrophosphate is synthesized from ribose-5-phosphate (Mg2+ is added, and ATP and ribose-5-phosphate are generated directly by

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