In the pentose-phosphate pathway, pentoses and NADPH are negative regulators, whereas the NADP+ and glucose-6-P enhance the pathway

The roles of pentoses and NADPH

  • Pentoses are needed for the synthesis of nucleotides and nucleic acids
  • NADPH is required for the neutralization of the peroxide form in RBC through the Glutathione system (GSS/GSSH), since peroxide can damage the RBCs

The irreversible, binding, speed determining step in the process is the glucose-6-phosphate dehydrogenase act.

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