Breast carcinoma

• Most common malignancy in women (except for skin carcinoma)
• Various of factors, but most important ones include estrogen exposure, age, genetics
  • In particular -- BRCA1/2 and TP53tumor suppressor genes
• Nearly all are adenocarcinomas
• The prevalence, tumor behavior and prognosis depend on the biologic and morphological features
• Biologic classification systems:
  • Based on the receptor expression
  • Based on genetic profiling
• Morphological classification:
  • Noninvasive (CIS)
  • Invasive

Biologic classification systems

ER = estrogen receptor, HER2 = human epidermal growth factor receptor 2, PR = progesterone receptor

• ER(+) and HER2(-)
  • In older women
  • Germline BRCA2 mutations
• HER2(+) and ER(+/-)
  • In younger women
  • Germline TP53 mutations
• Triple negative (ER,

Biologic classification systems

Noninvasive

Invasive

Grading

Staging

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