Leukemias are tumors of the bone marrow. In acute leukemias, the neoplastic cells are late hematopoietic cells (-cytes).

Description

In chronic leukemias, we see an accumulation of mature, mutated myeloid cells. The cells will undergo uncontrolled proliferation due to hyperactivated tyrosine kinases or other signaling pathway alterations.

  • Chronic leukemias have a slow progression, and they can progress into acute leukemias (but not the other way around!)
  • Incutable
  • Mostly affect older patients.

CML, polycythemia vera, essential thrombocythemia, and primary myelofibrosis

Chronic Myeloid Leukemia (CML)

Increased proliferation of (mainly) granulocytes.

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