Leukemias are tumors of the bone marrow. In acute leukemias, the neoplastic cells are late hematopoietic cells (-cytes).
Description
In chronic leukemias, we see an accumulation of mature, mutated myeloid cells. The cells will undergo uncontrolled proliferation due to hyperactivated tyrosine kinases or other signaling pathway alterations.
- Chronic leukemias have a slow progression, and they can progress into acute leukemias (but not the other way around!)
- Incutable
- Mostly affect older patients.
CML, polycythemia vera, essential thrombocythemia, and primary myelofibrosis
Chronic Myeloid Leukemia (CML)
Increased proliferation of (mainly) granulocytes.