As its name suggests, is a type of glomerulonephritis that quickly progresses to renal failure (within weeks to months).
The classic lesions include crescent formations which contain a cellular proliferation that fill up the Bowman's space.
RPGN can be primary (idiopathic) or secondary to another disease.
Classification
RPGN is classified into 5 entities based on the etiology, determined by histopathological findings, immunofluorescence, and serological tests for the presence of specific antibodies.
- Anti-GBM antibody mediated (RPGN type I)
- Linear deposition of IgG along the GBM (and often C3)
- Includes the anti-GBM GN and Goodpasture syndrome, which are the same, except Goodpasture has lung