Tyrosine kinase pathway, stable cyclin D generation, insulin signaling pathways

Signals

1. Growth factors
   1. EGF (epidermal)
   2. PDGF (derived from platelets)
   3. FGF (fibroblast)
2. Neurotrophins
3. Insulin

Receptors (tyrosine kinase) and the act of signaling (Figure 1)

1. The receptor has tyrosine kinase activity
2. Tyrosine side chains are phosphorylated by autophosphorylation, to which various proteins can bind with SH2-SH3 domains
3. Proteins which have SH3 domains can bind to the activated receptor such as src, PLC-gamma,

Signals

Receptors (tyrosine kinase) and the act of signaling (Figure 1)

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