Interaction between exercised induced Master Regulators: AMPK, SIRT1, PGC1α

Interaction between exercise-induced Master Regulators

1. AMPK (cooperating with SIRT1 activates PGC-1α)
2. SIRT1 (cooperating with AMPK activates PGC-1α)
3. PGC1α (increase the rate of transcription its own gene and activates the mitochondrial biogenesis)

The gene expression of skeletal muscle is regulated by

Interaction between exercise-induced Master Regulators

The gene expression of skeletal muscle is regulated by exercise

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