Eukaryotic genome organisation in general (definitions)
Description
- Chromatin: DNA + HISTONE proteins
- HISTONE PROTEINS: nucleosome formation
- H1 – nucleosome structural fixing
- H2A – component of nucleosome
- H2B – component of nucleosome
- H3 – component of nucleosome
- H4 – component of nucleosome
- H1 – nucleosome structural fixing
- NUCLEOSOME: Histones + DNA in a disc-unit
- octamer structure ( 4 + 4 Histones: H2A, H2B, H3, H4 )
- DNA wrapped around the histones
- HISTONE remodelling and modification:
- covalent modification of the core histones
- helps the activation of the heterochromatin into euchromatin
Classification
- EU-CHROMATIN:
- the transcriptionally active form of the DNA
- loosely