Special forms of rheumatoid arthritis – Felty, Caplan syndrome

Felty's syndrome

Felty's syndrome (FS) is a uncommon and severe form of RA in which innate immunity is severely reduced, leading to recurrent infections.

• FS is characterized by a triad of neutropenia, rheumatoid arthritis, and splenomegaly.
• Neutropenia is the most common and important feature (not all patients have splenomegaly or active RF).
• Etiology. The neutropenia is thought to be due to bone marrow failure, excessive NETosis, and their increased destruction in the spleen.

Felty’s syndrome

Caplan syndrome

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