Definitions
- Nuclear receptor family: Intracellular and nuclear receptors for hydrophobic hormones.
- Thyroid hormones
- Retinoid hormones
- Steroids
- 1,25-dihydroxy vitamin D3
Features
- Nuclear receptors have two domains
- DNA binding domain (DBD)
- Ligand-binding domain (LBD)
- Zinc- finger motifs are responsible for the DNA binding
- Act as transcription factors
- Different type of receptors are there
- They can form hetero or homo-dimers
Types of receptors
| Endocrine receptors | Endocrine receptors | Adopted “orphan receptors” | Orphan |