Direct antiglobulin test (direct Coombs test)

Checks for the presence of anti-RBC antibodies.

1. Blood sample is taken from a patient
2. RBCs are being washed and a Coombs reagent added
3. Coombs agent reacts with the Fc region of antibodies, or with C3b/C3d members of the complement system

If the mixture agglutinates, then the result if positive.

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