Make sure you cover the lymphomas article first.
Aggressive lymphomas are those lymphomas that are fast-growing and progressing, but they are generally considered curable.
They include:
- DLBCL
- Burkitt
- Mantle-cell
Diffuse large B-cell lymphoma
A group of B-cell lymphomas with a morphology resembling large and diffuse germinal centers in which there are large cells (3-4 times more than normal) with prominent nuclei.
- The most common type of Non-Hodgkin lymphomas (NHL) in adults.
- Divided into several groups with the largest group being DLBCL, NOS (non-specified).
- Presents with rapidly progressing lymphadenopathy typically involving extra-lymphatic tissues as well (bone marrow, GI, CNS, kidneys), with the GIT being most common.
- Can arise from follicular lymphoma.
- Associated with t(14;18), BCL2, BCL6, and MYC