Aplastic anemia

Aplastic anemia is anemia caused by bone marrow failure. It is characterized by bone marrow hypoplasia and pancytopenia.

• Typically appears in young (20) or older adults (>60).

Classification

• Severe (SAA)
  • Absolute reticulocyte count <50G/L
  • Platelet count <20G/L
  • Absolute neutrophil count <0.5G/L
• Very severe (vSAA)
  • Severe + absolute neutrophil count <0.2G/L
• Moderate
  • Values above severe (not fulfilling the criteria)

Etiology

Aplastic anemia can be primary (idiopathic or congenital) or secondary.

Idiopathic aplastic anemia

Most common

Classification

Etiology

Idiopathic aplastic anemia

Congenital – Fanconi anemia (FA)

Secondary aplastic anemia

Clinical presentation

Diagnosis

Treatment

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