Paroxysmal nocturnal hemoglobinuria is an acquired clonal cell disorder leading to intra- and extravascular hemolysis.

Pathophysiology

Paroxysmal nocturnal hemoglobinuria is an acquired mutation in the PIGA (phosphatidylinositol glycan) gene which is required for the synthesis of GPI links or "PIG tails". GPI links attach surface markers (CD55

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