{"id":9324,"date":"2021-12-19T00:23:58","date_gmt":"2021-12-18T22:23:58","guid":{"rendered":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/immunology\/mixed-connective-tissue-disease-mctd\/"},"modified":"2021-12-23T22:16:26","modified_gmt":"2021-12-23T20:16:26","slug":"mixed-connective-tissue-disease-mctd","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/immunology\/mixed-connective-tissue-disease-mctd\/","title":{"rendered":"Mixed connective tissue disease (MCTD)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">MCTD is defined as a disorder characterized by the presence of anti-U1 ribonucleoprotein (RNP) antibody, along with symptoms of SLE, systemic sclerosis, and polymyositis.<\/p>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Symptoms<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">Initially, may resemble an undifferentiated connective tissue disease.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Raynaud phenomenon (first symptom)<\/li><li>Swelling of the hands<\/li><li>Rashes similar to dermatomyositis or SLE, sclerosis of the skin<\/li><li>Arthritis<\/li><li>Proximal muscle weakness<\/li><li>Renal involvement (nephritis)<\/li><li>Pulmonary involvement (pulmonary HTN and fibrosis, most often the cause of death)<\/li><li>Esophageal dysmobility<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Diagnosis<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">The presence of both the symptoms and anti-U1 RNP antibodies is necessary for the diagnosis.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood panel (ESR, CK)<\/li><li>Serology<ul><li>ANAs<\/li><li>RF<\/li><li>Anti-U1 RNP antibodies<\/li><\/ul><\/li><li>ECG (pulmonary HTN)<\/li><li>EMG<\/li><li>MRI<\/li><li>Muscle biopsy<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Treatment<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<ul class=\"wp-block-list\"><li>In mild cases, antimalarials (hydroxychloroquine) and NSAIDs<\/li><li>In mild-to-severe cases, corticosteroids and DMARDs (methotrexata, mycophenolate mofetil, azathioprine)<\/li><li>CCB and prozasin, smoking cessation, avoid cold (Raynaud phenomenon)<\/li><\/ul>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Symptoms<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Diagnosis<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Treatment<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>MCTD is defined as a disorder characterized by the presence of anti-U1 ribonucleoprotein (RNP) antibody, along with symptoms of SLE, systemic sclerosis, and polymyositis. Symptoms Initially, may resemble an undifferentiated connective tissue disease. Raynaud phenomenon (first symptom) Swelling of the hands Rashes similar to dermatomyositis or SLE, sclerosis of the skin Arthritis Proximal muscle weakness [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":9306,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9324","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mixed connective tissue disease (MCTD) &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/immunology\/mixed-connective-tissue-disease-mctd\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/clinical\\\/internal-medicine\\\/immunology\\\/mixed-connective-tissue-disease-mctd\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/clinical\\\/internal-medicine\\\/immunology\\\/mixed-connective-tissue-disease-mctd\\\/\",\"name\":\"Mixed connective tissue disease (MCTD) &#8211; 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