{"id":8103,"date":"2021-11-15T22:59:47","date_gmt":"2021-11-15T20:59:47","guid":{"rendered":"https:\/\/meddists.com\/learn\/clinical\/nephrology\/acute-interstitial-nephritis\/"},"modified":"2021-11-15T23:02:08","modified_gmt":"2021-11-15T21:02:08","slug":"acute-interstitial-nephritis","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/nephrology\/acute-interstitial-nephritis\/","title":{"rendered":"Acute interstitial nephritis"},"content":{"rendered":"\n

AIN is a type of tubulointerstitial nephritis; there are acute <\/strong>and chronic <\/strong>interstitial nephritis. The term interstitial nephritis generally means non-infectious TIN.<\/p>\n\n\n\n

AKI is characterized by inflammation of the renal interstitium<\/strong> (the tissue surrounding the glomeruli and tubules), usually days <\/strong>to a few weeks<\/strong> after the triggering event<\/strong>.<\/p>\n\n\n\n

Clinically, similar to ATN; the only way to distinguish between the two is a renal biopsy<\/strong> (which is not taken often).<\/p>\n\n\n\n

Etiology<\/h4>\n<\/span>\n\n\n
  • Most causes are due to allergic reaction to drugs<\/strong> (penicillin, sulfamethoxazole, diuretics, anticoagulants, phenytoin, rifampin, PPIs).<\/li>
  • Other causes include infections<\/strong> (Strep, Legionella), sarcoidosis, SLE, Sjorgen disease<\/li><\/ul>\n\n\n<\/span>\n

    Symptoms<\/h4>\n<\/span>\n\n\n
    • Presents with acute renal insufficiency<\/strong> (azotemia, anuria\/oliguria), fever<\/strong>, rash<\/strong>, eosinophillia<\/strong>. Sterile pyuria.<\/strong><\/li><\/ul>\n\n\n\n
      • Abdominal pain, weight loss, and bilateral renal enlargement <\/strong>(caused by interstitial edema) may also occur in ATIN and with fever may mistakenly suggest renal cancer or polycystic kidney disease.<\/li><\/ul>\n\n\n<\/span>\n

        Diagnosis<\/h4>\n<\/span>\n\n\n
        • Increased BUN<\/strong> and Cr <\/strong>levels<\/li>
        • Urinalysis<\/strong>: Eosinophils (non-specific), WBC casts, mild proteinuria, and hematuria<\/li>
        • US<\/strong>: enlarged and echogenic kidneys (inflammation)<\/li>
        • Biopsy<\/strong>: only taken in uncertain diagnosis, no improvement\/progression,<\/li><\/ul>\n\n\n<\/span>\n

          Management<\/h4>\n<\/span>\n\n\n
          • Remove offending agent,<\/strong> treat the infection. Recovery takes 6-8 weeks<\/li>
          • Corticoids<\/strong><\/li><\/ul>\n<\/span>

            Etiology<\/h4>

            Symptoms<\/h4>

            Diagnosis<\/h4>

            Management<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

            AIN is a type of tubulointerstitial nephritis; there are acute and chronic interstitial nephritis. The term interstitial nephritis generally means non-infectious TIN. AKI is characterized by inflammation of the renal interstitium (the tissue surrounding the glomeruli and tubules), usually days to a few weeks after the triggering event. Clinically, similar to ATN; the only way […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":685,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8103","page","type-page","status-publish","hentry"],"yoast_head":"\nAcute interstitial nephritis – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/nephrology\/acute-interstitial-nephritis\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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