{"id":7587,"date":"2021-10-17T18:04:52","date_gmt":"2021-10-17T16:04:52","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/regulatory-mechanism-in-glucose-metabolism-ii\/"},"modified":"2021-10-21T11:00:03","modified_gmt":"2021-10-21T09:00:03","slug":"regulatory-mechanism-in-glucose-metabolism-ii","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/regulatory-mechanism-in-glucose-metabolism-ii\/","title":{"rendered":"Regulatory mechanism in glucose metabolism II."},"content":{"rendered":"\n

The regulation of the pathways can be done by:<\/p>\n\n\n\n
  1. allosteric small molecules (ATP, ADP, cAMP, NADH, NAD+<\/sup>)<\/li>
  2. end products of the reaction<\/li>
  3. calcium or magnesium<\/li>
  4. hormones<\/li><\/ol>\n\n\n\n

    <\/div><\/p>\n\n\n\n

    Regulation of the gluconeogenesis<\/p>\n\n\n\n

    Allosteric way lot of enzymes are regulated in gluconeogenesis, however, there are four enzymes that play a critical role in gluconeogenesis (Figure 1):<\/p>\n\n\n\n

    1. Pyruvate carboxylase<\/li>
    2. PEP carboxykinase<\/li>
    3. F-1,6Bisphosphatase<\/li>
    4. G-6-Phosphatase<\/li><\/ol>\n\n\n\n
      \"\"<\/a>
      Figure 1. Regulation of gluconeogenesis<\/strong><\/figcaption><\/figure><\/div>\n\n\n\n

      (See details in Gluconeogenesis<\/a>)<\/p>\n\n\n\n

      Glucagon and insulin are dominating while regulation:
      Glucagon activates the PEP Carboxykinase, and Insulin inhibits it, while the same regulation happens with the ACETYL-COA and insulin in the case of the Pyruvate carboxylase enzyme.<\/p>\n\n\n\n

      ATP\/AMP levels are regulating the F-1,6-BisPhosphatase meanwhile the level of the G-6-P and Glucose regulates the G-6-Phosphatase activity.<\/p>\n\n\n\n

      References<\/h2>\n<\/span>\n\n\n

      Snider MDS. Devlin\u2019s Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley & Sons, Incorporated, 2020; 2019.<\/span> <\/p>\n\n\n\n

      <\/p>\n<\/span>

      References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"

      Regulation of the gluconeogenesis Allosteric way lot of enzymes are regulated in gluconeogenesis, however, there are four enzymes that play a critical role in gluconeogenesis (Figure 1): Pyruvate carboxylase PEP carboxykinase F-1,6Bisphosphatase G-6-Phosphatase (See details in Gluconeogenesis) Glucagon and insulin are dominating while regulation: Glucagon activates the PEP Carboxykinase, and Insulin inhibits it, while the […]<\/p>\n","protected":false},"author":23,"featured_media":0,"parent":1711,"menu_order":19,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7587","page","type-page","status-publish","hentry"],"yoast_head":"\nRegulatory mechanism in glucose metabolism II. – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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