{"id":7179,"date":"2021-10-02T12:14:15","date_gmt":"2021-10-02T10:14:15","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/lactate-cycle-exercising\/"},"modified":"2021-10-02T21:25:02","modified_gmt":"2021-10-02T19:25:02","slug":"lactate-cycle-exercising","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/lactate-cycle-exercising\/","title":{"rendered":"Lactate cycle – Exercising"},"content":{"rendered":"\n

There is no such a lactate cycle in your body, there is one which is the new shuttle, but this topic describes the phenomenon of muscle pain and its relief after 2-3 days for the “gym-rats” <\/div><\/p>\n\n\n\n

How lactate is produced in the muscles?<\/h2>\n<\/span>\n\n\n
\"\"<\/a>
Figure 1. Lactate production from Pyruvate<\/strong><\/figcaption><\/figure><\/div>\n\n\n\n

Lactate is produced when the oxygen level is lower<\/strong>, while the muscles are continuously contracting. If there is no rest<\/strong> between the muscle work the pyruvate is converted into lactate<\/strong> with the help of the lactate dehydrogenase enzyme<\/strong> (LDH).<\/p>\n\n\n<\/span>\n

But how it really looks like in real life?<\/h2>\n<\/span>\n\n\n
  1. You have decided to be a bodybuilder<\/li>
  2. You went down the gym and like a maniac without any rest between the sets you were exercising<\/li>
  3. Day 1 after … the muscles are in pain (it is also caused by the micro-wounds of the muscle fibers)<\/li>
  4. Day 2 after … the pain is less<\/li>
  5. Day 3 after … the pain is even less<\/li>
  6. Day 4 after … the pain is gone<\/li><\/ol>\n\n\n\n
    \"\"<\/a>
    Figure 2. Lactate shuffle between the organs<\/strong><\/figcaption><\/figure><\/div>\n\n\n\n
    1. The muscles are using the glucose you ate before\/ the glucose which came from the gylcogen storages<\/li>
    2. Glycolysis started and pyruvate is produced<\/li>
    3. Without any rest between the sets, muscles are lacking the oxygen, while pyruvate is converted into lactate<\/li>
    4. Lactate is accumulating in the tissue<\/li>
    5. Blood and RBCs transporting the lactate into the liver, where the gluconeogenesis initiated<\/li>
    6. Lactate turns back into pyruvate with LDH<\/li>
    7. Pyruvate turns back into glucose by Gluconeogenesis<\/li>
    8. Glucose is secreted into the bloodstream<\/li>
    9. Glucuse reaches the muscles, glycolysis is activated, pyruvate is produced<\/li>
    10. Due to the fact that the tissue is resting , sustainable level of oxygen are there, Acetyl-Coa is produced<\/li>
    11. TCA cycle is active, ATP is produced afterwards<\/li><\/ol>\n\n\n<\/span>\n

      References<\/h2>\n<\/span>\n\n\n

      Snider MDS. Devlin\u2019s Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley & Sons, Incorporated, 2020; 2019.<\/span> <\/p>\n<\/span>

      How lactate is produced in the muscles?<\/h2>

      But how it really looks like in real life?<\/h2>

      References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"

      How lactate is produced in the muscles? Lactate is produced when the oxygen level is lower, while the muscles are continuously contracting. If there is no rest between the muscle work the pyruvate is converted into lactate with the help of the lactate dehydrogenase enzyme (LDH). But how it really looks like in real life? […]<\/p>\n","protected":false},"author":23,"featured_media":0,"parent":1711,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7179","page","type-page","status-publish","hentry"],"yoast_head":"\nLactate cycle - Exercising – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/lactate-cycle-exercising\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/carbohydrate-metabolism\\\/lactate-cycle-exercising\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/carbohydrate-metabolism\\\/lactate-cycle-exercising\\\/\",\"name\":\"Lactate cycle - 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