{"id":6826,"date":"2021-09-14T20:09:53","date_gmt":"2021-09-14T18:09:53","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-pathology\/wilsons-disease\/"},"modified":"2021-09-14T20:10:17","modified_gmt":"2021-09-14T18:10:17","slug":"wilsons-disease","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/wilsons-disease\/","title":{"rendered":"Wilson&#8217;s disease"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Excessive amounts of copper within tissues.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Due to impaired excretion into the bile and failure to incorporate the copper into ceruloplasmin which is the main copper carrier protein<\/li><li>The liver will undergo steatosis, hepatitis, and cirrhosis with prominent <strong>Mallory-Denk<\/strong> bodies<\/li><li>Once unbound copper is released from damaged hepatocytes, it will lead to:<ul><li>RBC lysis<\/li><li>Deposition in the brain, cornea, kidneys, bone<\/li><li><strong>Kayser-Fleischer rings<\/strong> in the cornea<\/li><\/ul><\/li><li>Diagnosis &#8212; low levels of serum ceruloplasmin, increased hepatic copper<\/li><\/ul>\n<div id=\"the_titles\" style=\"display:none;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Excessive amounts of copper within tissues. Due to impaired excretion into the bile and failure to incorporate the copper into ceruloplasmin which is the main copper carrier protein The liver will undergo steatosis, hepatitis, and cirrhosis with prominent Mallory-Denk bodies Once unbound copper is released from damaged hepatocytes, it will lead to: RBC lysis Deposition [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":6822,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6826","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Wilson&#039;s disease &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/wilsons-disease\/\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/wilsons-disease\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/wilsons-disease\\\/\",\"name\":\"Wilson's disease &#8211; 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