{"id":6824,"date":"2021-09-14T20:09:52","date_gmt":"2021-09-14T18:09:52","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-pathology\/hemochromatosis\/"},"modified":"2021-09-14T20:10:07","modified_gmt":"2021-09-14T18:10:07","slug":"hemochromatosis","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/","title":{"rendered":"Hemochromatosis"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Excessive amounts of iron within tissues.<\/p>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Etiology<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ul class=\"wp-block-list\"><li>Over administration of iron, or excessive RBC breakdown<\/li><li>Defect in&nbsp;<strong>hepcidin <\/strong>protein which regulates iron metabolism<ul><li>Most commonly, a genetic defect in <strong>HFE&nbsp;<\/strong>regulating the synthesis of hepcidin<\/li><\/ul><\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Consequences<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<ul class=\"wp-block-list\"><li>Cirrhosis<\/li><li>Diabetes mellitus and pancreatic fibrosis<\/li><li>Abnormal skin pigmentation<\/li><li>Dilitative cardiomyopathy<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Mechanisms<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<ul class=\"wp-block-list\"><li>Direct DNA damage<\/li><li>Lipid peroxidation<\/li><li>Stimulation of collagen formation<\/li><\/ul>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Etiology<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Consequences<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Mechanisms<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>Excessive amounts of iron within tissues. Etiology Over administration of iron, or excessive RBC breakdown Defect in&nbsp;hepcidin protein which regulates iron metabolism Most commonly, a genetic defect in HFE&nbsp;regulating the synthesis of hepcidin Consequences Cirrhosis Diabetes mellitus and pancreatic fibrosis Abnormal skin pigmentation Dilitative cardiomyopathy Mechanisms Direct DNA damage Lipid peroxidation Stimulation of collagen formation [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":6822,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6824","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hemochromatosis &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/hemochromatosis\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/hemochromatosis\\\/\",\"name\":\"Hemochromatosis &#8211; Meddists\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/#website\"},\"datePublished\":\"2021-09-14T18:09:52+00:00\",\"dateModified\":\"2021-09-14T18:10:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/hemochromatosis\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/hemochromatosis\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/hemochromatosis\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\\\/\\\/meddists.com\\\/learn\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pre-clinical\",\"item\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Pathology\",\"item\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Liver and gallbladder pathology\",\"item\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/liver-and-gallbladder-pathology\\\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Hemochromatosis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/#website\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/\",\"name\":\"Meddists\",\"description\":\"Let&#039;s Get Studying\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/meddists.com\\\/learn\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hemochromatosis &#8211; Meddists","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/","url":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/","name":"Hemochromatosis &#8211; Meddists","isPartOf":{"@id":"https:\/\/meddists.com\/learn\/#website"},"datePublished":"2021-09-14T18:09:52+00:00","dateModified":"2021-09-14T18:10:07+00:00","breadcrumb":{"@id":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/hemochromatosis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/meddists.com\/learn\/"},{"@type":"ListItem","position":2,"name":"Pre-clinical","item":"https:\/\/meddists.com\/learn\/pre-clinical\/"},{"@type":"ListItem","position":3,"name":"Pathology","item":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/"},{"@type":"ListItem","position":4,"name":"Liver and gallbladder pathology","item":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/liver-and-gallbladder-pathology\/"},{"@type":"ListItem","position":5,"name":"Hemochromatosis"}]},{"@type":"WebSite","@id":"https:\/\/meddists.com\/learn\/#website","url":"https:\/\/meddists.com\/learn\/","name":"Meddists","description":"Let&#039;s Get Studying","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/meddists.com\/learn\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/6824","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/comments?post=6824"}],"version-history":[{"count":2,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/6824\/revisions"}],"predecessor-version":[{"id":6834,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/6824\/revisions\/6834"}],"up":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/6822"}],"wp:attachment":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/media?parent=6824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}