{"id":6694,"date":"2021-09-13T21:48:54","date_gmt":"2021-09-13T19:48:54","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/nervous-system\/prion-diseases\/"},"modified":"2021-09-13T21:49:09","modified_gmt":"2021-09-13T19:49:09","slug":"prion-diseases","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/nervous-system\/prion-diseases\/","title":{"rendered":"Prion diseases"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A group of infectious diseases in which the causative agent is an abnormal form of a normal cellular protein.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Caused by a prion protein (PrP)<ul><li>Changes from alpha-helical to beta-sheets &#8212; resistant to protease PrP<sup>res<\/sup><\/li><li>Can &#8220;infect&#8221; normal PrP to turn into PrP<sup>res<\/sup><ul><li>Self-amplification<\/li><\/ul><\/li><li>Causes cellular injury<\/li><\/ul><\/li><li>Caused spontaneously (sporadic), inherited (familial) or transmitted (infective)<\/li><li>Examples:<ul><li>Crutzfeldt-Jakov disease<\/li><li>Fatal familial insomnia<\/li><li>Kuru<\/li><li>&#8220;Mad-cow&#8221; disease<\/li><\/ul><\/li><\/ul>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Crutzfeldt-Jakob disease<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ul class=\"wp-block-list\"><li>Rare, fatal dementing disease, leading to death within half a year<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Etiology<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<ul class=\"wp-block-list\"><li>Sporadic &#8212; Most cases<\/li><li>Familial<\/li><li>Infective &#8212; During operations<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Morphology<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<p class=\"wp-block-paragraph\">Spongiform transformation of the cerebral cortex and deep gray matter structures (caudate, putamen), without inflammation.<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_4\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Fatal familial insomnia<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_4\">\n\n\n<p class=\"wp-block-paragraph\">The striking difference is the lack of spongiform transformation.<\/p>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Crutzfeldt-Jakob disease<\/h3><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Etiology<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Morphology<\/h4><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Fatal familial insomnia<\/h3><\/div>","protected":false},"excerpt":{"rendered":"<p>A group of infectious diseases in which the causative agent is an abnormal form of a normal cellular protein. Caused by a prion protein (PrP) Changes from alpha-helical to beta-sheets &#8212; resistant to protease PrPres Can &#8220;infect&#8221; normal PrP to turn into PrPres Self-amplification Causes cellular injury Caused spontaneously (sporadic), inherited (familial) or transmitted (infective) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":6651,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6694","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prion diseases &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/nervous-system\/prion-diseases\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/nervous-system\\\/prion-diseases\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/nervous-system\\\/prion-diseases\\\/\",\"name\":\"Prion diseases &#8211; 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