{"id":617,"date":"2020-02-14T07:13:48","date_gmt":"2020-02-14T07:13:48","guid":{"rendered":"https:\/\/meddists.com\/learn\/?page_id=617"},"modified":"2020-02-14T07:13:48","modified_gmt":"2020-02-14T07:13:48","slug":"muscle-tissue-tumors","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/soft-tissue-tumors\/muscle-tissue-tumors\/","title":{"rendered":"Muscle tissue tumors"},"content":{"rendered":"\n

Muscle tissue tumors are classified according to the type of muscle tissue.<\/p>\n\n\n\n

Striated muscle<\/h3>\n<\/span>\n\n\n

Most striated muscle tumors are of a malignant<\/strong> nature (rhabdomyosarcomas<\/strong>).<\/p>\n\n\n<\/span>\n

Rhabdomyosarcoma<\/h4>\n<\/span>\n\n\n
  • Malignant<\/strong><\/li>
  • Aggressive<\/li>
  • Most common soft-tissue sarcoma in children and young adults<\/li>
  • Three subtypes exist (ordered by the degree of malignancy):
    • Embryonal <\/strong>(most cases)
      • Most commonly found in the head and neck regions of children (ages 3-12)
        • Mostly in regions absent of skeletal muscle<\/li>
        • Consists of round (tadpole) and spindle (strap) cells<\/li><\/ul><\/li>
        • Sarcoma botryoides\u00a0<\/strong>is a variant of embryonal rhabdomyosarcoma that develops in walls of hollow viscera (vagina, bladder)<\/li><\/ul><\/li>
        • Alveolar<\/strong>
          • Most commonly found in the upper and lower extremities of young people (ages 10-25)<\/li>
          • Resembles the alveolar tissue in the lungs, but has nothing to do with the lungs<\/strong><\/li><\/ul><\/li>
          • Pleomorphic<\/strong>
            • Most commonly found in skeletal muscles (thigh) of adults<\/li><\/ul><\/li><\/ul><\/li>
            • The botryoid variant of embryonal rhabdomyosarcoma has the best prognosis, and the pleomorphic has the worst<\/li>
            • Most cases are curable, using surgery and chemotherapy<\/li><\/ul>\n\n\n<\/span>\n

              Rhabdomyoma<\/h4>\n<\/span>\n\n\n
              • Extremely rare<\/li>
              • Benign<\/strong> tumor<\/li>
              • Believed to arise from fetal striated muscle tissue (commonly\u00a0the heart)<\/li><\/ul>\n\n\n<\/span>\n

                Smooth muscle<\/h3>\n<\/span>\n\n\n

                Opposed to skeletal muscle tumors — most smooth muscle tumors are benign<\/strong> (leiomyomas).<\/p>\n\n\n<\/span>\n

                Leiomyoma<\/h4>\n<\/span>\n\n\n
                • Benign<\/li>
                • Can arise in any soft tissue site
                  • Most often in the uterus (myometrium)
                    • Can be classified according to its location (submucosal, intramural, subserosal)<\/li>
                    • Can cause infertility and menorrhagia (severe menstrual bleeding)<\/li><\/ul><\/li>
                    • Other examples include pilar leiomyoma (arise from the erector pili muscles), gastrointestinal tract, etc.<\/li>
                    • Usually, arises from the muscular tissue<\/li><\/ul><\/li>
                    • Histologically, a capsulated, whorled lesion is observed<\/li>
                    • Loss of function mutation of the FH (fumarate hydratase) gene is commonly seen<\/li><\/ul>\n\n\n<\/span>\n

                      Leiomyosarcoma<\/h4>\n<\/span>\n\n\n
                      • Malignant<\/li>
                      • Occur mostly in adult women<\/li>
                      • Most common sites are the retroperitoneum, the limbs, and great vessel walls
                        • Usually, arises from the connective tissue around the smooth muscle<\/li><\/ul><\/li>
                        • Histologically, abundant mitotic figures and necrosis is observed<\/li>
                        • The lungs are a common site for metastasis<\/li><\/ul>\n<\/span>

                          Striated muscle<\/h3>

                          Rhabdomyosarcoma<\/h4>

                          Rhabdomyoma<\/h4>

                          Smooth muscle<\/h3>

                          Leiomyoma<\/h4>

                          Leiomyosarcoma<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

                          Muscle tissue tumors are classified according to the type of muscle tissue. Striated muscle Most striated muscle tumors are of a malignant nature (rhabdomyosarcomas). Rhabdomyosarcoma Malignant Aggressive Most common soft-tissue sarcoma in children and young adults Three subtypes exist (ordered by the degree of malignancy): Embryonal (most cases) Most commonly found in the head and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":607,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-617","page","type-page","status-publish","hentry"],"yoast_head":"\nMuscle tissue tumors – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/soft-tissue-tumors\/muscle-tissue-tumors\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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