{"id":613,"date":"2020-02-14T07:09:16","date_gmt":"2020-02-14T07:09:16","guid":{"rendered":"https:\/\/meddists.com\/learn\/?page_id=613"},"modified":"2020-02-14T07:09:17","modified_gmt":"2020-02-14T07:09:17","slug":"diagnosis-of-soft-tissue-tumors","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/soft-tissue-tumors\/diagnosis-of-soft-tissue-tumors\/","title":{"rendered":"Diagnosis of soft tissue tumors"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">When diagnosing a soft tissue tumor, the same diagnostic methods apply as for other tumors.<\/p>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Tissue pattern<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">Knowing the histological morphology, we can usually identify the tissue type of the tumor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Intensely eosinophilic fascicles&nbsp;<\/strong>(muscle tissue)<\/li><li><strong>Cartwheel&nbsp;<\/strong>(<strong>storiform<\/strong>)&nbsp;<strong>pattern<\/strong><\/li><li><strong>Herringbone pattern<\/strong>&nbsp;(resemblance to the bones of a fish such as a herring)<\/li><li><strong>Palisaded pattern&nbsp;<\/strong>(nuclei seem piled upon each other)<\/li><li><strong>Biphasic pattern&nbsp;<\/strong>(two types of arrangements)<\/li><\/ul>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"https:\/\/meddists.com\/wp-content\/uploads\/2019\/02\/soft_tissue_tumors_v2.jpg\" target=\"_blank\" title=\"Diagnosis of soft tissue tumors\"><img decoding=\"async\" src=\"https:\/\/meddists.com\/wp-content\/uploads\/2019\/02\/soft_tissue_tumors_v2-600x120.jpg\" alt=\"\" class=\"wp-image-9285\"\/><\/a><figcaption> <strong>From left to right: Demonstration of the patterns written above (leiomyoma, storiform collagenoma,\u00a0malignant peripheral nerve sheath tumor, peripheral schwannoma, synovial sarcoma)<\/strong> (Credit: Adapted from the work of LWozniak&amp;KWZielinski,\u00a0Ed Uthman,\u00a0Nephron, and\u00a0Bjbedke, CC BY-SA 4.0)<\/figcaption><\/figure><\/div>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Cell morphology<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">After we&#8217;ve recognized the tissue pattern, we can zoom-in and recognize the morphology and type of individual cells:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Spindle cells<\/strong> &#8212; Narrow elongated cells. Most common type<ul><li><strong>Fibrogenic<\/strong>&nbsp;&#8212; Light-pink cytoplasm, tip-shaped nuclei<\/li><li><strong>Neurogenic<\/strong> &#8212; Light-pink cytoplasm, curved nuclei<\/li><li><strong>Leiomyomatous&nbsp;<\/strong>&#8212;&nbsp;Intensely eosinophilic, cigar-shaped nuclei<\/li><li><strong>Skeletal muscle&nbsp;<\/strong>&#8212; Same as leiomyomatous, but with striations<\/li><\/ul><\/li><li><strong>Small, round cells<\/strong><\/li><li><strong>Epithelioid cells&nbsp;<\/strong>&#8212; Epithelial-like<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Immunohistochemistry<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<p class=\"wp-block-paragraph\">Using antibodies to identify specific markers of cells. High-yield\u00a0examples:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"\"><tbody><tr><td><strong>Tissue type<\/strong><\/td><td><strong>Marker<\/strong><\/td><\/tr><tr><td>Smooth muscle<\/td><td>Smooth muscle actin (SMA)<\/td><\/tr><tr><td>Skeletal muscle<\/td><td>Desmin<\/td><\/tr><tr><td>Mesenchymal cells<\/td><td>Vimentin<\/td><\/tr><tr><td>Nerve fibers<\/td><td>S100<\/td><\/tr><tr><td>Vascular endothelium<\/td><td>Factor VIII<\/td><\/tr><tr><td>Lymphoid cells<\/td><td> Lymphocyte common antigen (LCA) <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n<\/span><span class=\"block-heading\" id=\"header_4\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Cytogenetics<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_4\">\n\n\n<p class=\"wp-block-paragraph\">Identifying specific cytogenic aberrations which are known to be common.<\/p>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Tissue pattern<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Cell morphology<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Immunohistochemistry<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Cytogenetics<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>When diagnosing a soft tissue tumor, the same diagnostic methods apply as for other tumors. Tissue pattern Knowing the histological morphology, we can usually identify the tissue type of the tumor: Intensely eosinophilic fascicles&nbsp;(muscle tissue) Cartwheel&nbsp;(storiform)&nbsp;pattern Herringbone pattern&nbsp;(resemblance to the bones of a fish such as a herring) Palisaded pattern&nbsp;(nuclei seem piled upon each other) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":607,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-613","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Diagnosis of soft tissue tumors &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/soft-tissue-tumors\/diagnosis-of-soft-tissue-tumors\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/soft-tissue-tumors\\\/diagnosis-of-soft-tissue-tumors\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/pathology\\\/soft-tissue-tumors\\\/diagnosis-of-soft-tissue-tumors\\\/\",\"name\":\"Diagnosis of soft tissue tumors &#8211; 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