{"id":607,"date":"2020-02-14T06:56:54","date_gmt":"2020-02-14T06:56:54","guid":{"rendered":"https:\/\/meddists.com\/learn\/?page_id=607"},"modified":"2020-02-14T07:00:10","modified_gmt":"2020-02-14T07:00:10","slug":"soft-tissue-tumors","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/soft-tissue-tumors\/","title":{"rendered":"Soft tissue tumors"},"content":{"rendered":"\n

Definition<\/h4>\n<\/span>\n\n\n

Soft tissue<\/strong> is defined as the supportive tissue of various organs and the nonepithelial, extraskeletal structures except for the lymphohematopoietic tissues.<\/p>\n\n\n\n

This includes:<\/p>\n\n\n\n

  • Muscle tissue (skeletal, smooth, cardiac)<\/li>
  • Fibrous tissue<\/li>
  • Synovial tissue<\/li>
  • Adipose tissue<\/li>
  • Blood vessels<\/li>
  • Neuroectodermal tissues<\/li><\/ul>\n\n\n<\/span>\n

    Origin<\/h4>\n<\/span>\n\n\n

    The direct origin of soft tissue tumors is unknown.<\/p>\n\n\n\n

    It is, however, presumed that the tumors arising from these tissues generally begin as undifferentiated mesenchymal cells (MSCs — mesenchymal stem cells)<\/em>. The cells underwent multiple chromosomal alterations (in the majority of cases) or single-gene mutations (remainder of cases)<\/em>.<\/p>\n\n\n<\/span>\n

    Characteristics<\/h4>\n<\/span>\n\n\n

    Generally speaking, soft-tissue tumors:<\/p>\n\n\n\n

    • Can arise everywhere in the body, but most commonly in the lower extremities and the abdomen<\/li>
    • More common in males<\/li>
    • Over 200 subtypes have been discovered.<\/li><\/ul>\n\n\n<\/span>\n

      Classifications<\/h4>\n<\/span>\n\n\n

      As with other tumors, we classify them by their nature — varying on their level of malignancy (with 4 WHO classifications depending on their behavior — discussed below). Malignant soft-tissue tumors are collectively known as sarcomas<\/strong>.<\/p>\n\n\n\n

      The general characteristics of malignant<\/strong>\u00a0soft-tissue\u00a0tumors include:<\/p>\n\n\n\n

      Characteristic<\/strong><\/td>Benign<\/strong><\/td>Malignant<\/strong><\/td><\/tr>
      Frequency<\/td>Common<\/td>Rare<\/td><\/tr>
      Location<\/td>Superficial<\/td>Deep<\/td><\/tr>
      Size<\/td>Small<\/td>Large<\/td><\/tr>
      Growth rate<\/td>Slow<\/td>Fast<\/td><\/tr>
      Angiogenesis<\/td>No<\/td>Yes<\/td><\/tr>
      Metastasis<\/td>No*<\/td>Yes<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

      *On extremely rare occasions, a benign tumor can metastasize (dislodging neoplastic cells during surgical interventions).<\/p>\n\n\n<\/span>\n

      WHO Classifications1<\/sup><\/h4>\n<\/span>\n\n\n
      • Benign<\/strong>
        • Do not metastasize<\/li>
        • Do not invade or destroy nearby tissues<\/li>
        • For example — Lipomas<\/li><\/ul><\/li>
        • Intermediate (locally invasive)<\/strong>
          • Do not metastasize<\/li>
          • Invade and destroy nearby tissues<\/li>
          • For example — Desmoid tumors<\/li><\/ul><\/li>
          • Intermediate (rarely metastasizing)<\/strong>
            • 2% of the tumors metastasize<\/li>
            • Invade and destroy nearby tissues<\/li>
            • For example —\u00a0Dermatofibrosarcoma protuberans<\/li><\/ul><\/li>
            • Malignant<\/strong>
              • Tumors readily metastasize<\/li>
              • Invade and destroy nearby tissues<\/li><\/ul><\/li><\/ul>\n\n\n\n
                1. D. M. Fletcher C. WHO Classification of Tumours of Soft Tissue and Bone<\/em>. World Health Organization; 2013. <\/li><\/ol>\n<\/span>

                  Definition<\/h4>

                  Origin<\/h4>

                  Characteristics<\/h4>

                  Classifications<\/h4>

                  WHO Classifications1<\/sup><\/h4><\/div>","protected":false},"excerpt":{"rendered":"

                  Definition Soft tissue is defined as the supportive tissue of various organs and the nonepithelial, extraskeletal structures except for the lymphohematopoietic tissues. This includes: Muscle tissue (skeletal, smooth, cardiac) Fibrous tissue Synovial tissue Adipose tissue Blood vessels Neuroectodermal tissues Origin The direct origin of soft tissue tumors is unknown. It is, however, presumed that the […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":402,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-607","page","type-page","status-publish","hentry"],"yoast_head":"\nSoft tissue tumors – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/pathology\/soft-tissue-tumors\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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