{"id":5797,"date":"2021-05-28T01:07:55","date_gmt":"2021-05-27T23:07:55","guid":{"rendered":"https:\/\/meddists.com\/learn\/clinical\/hematology\/thrombocytopenia-and-platelet-disorders\/antidotes-to-antithrombotics\/"},"modified":"2021-05-28T01:23:25","modified_gmt":"2021-05-27T23:23:25","slug":"antidotes-to-antithrombotics","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/thrombocytopenia-and-platelet-disorders\/antidotes-to-antithrombotics\/","title":{"rendered":"Antidotes to antithrombotics"},"content":{"rendered":"\n

Antithrombotics<\/h4>\n<\/span>\n\n\n
  • Anticoagulants (UFH, LMWH, coumarin, Xarelto=Rivaroxaban, Pradaxa=Dabigatran)<\/li>
  • Antiplatelets (ASA, clopidogrel, GPIIb\/IIIa blocking agents=Abciximab)<\/li>
  • Thrombolytics (Streptokinase=SK, rtPA=Actilyse)<\/li><\/ul>\n\n\n<\/span>\n

    Labratory tests<\/h4>\n<\/span>\n\n\n
    \"\"<\/figure>\n\n\n<\/span>\n

    Antidotes<\/h4>\n<\/span>\n\n\n
    Antithrombotic<\/th>Antidote<\/th><\/tr><\/thead>
    Heparin (UFH)<\/td>Protamine sulfate (1-2ml iv.)<\/td><\/tr>
    LMWH<\/td>Protamine sulfate (>30%)<\/td><\/tr>
    Coumarol<\/td>Vit K injection 1.25-10mg
    FFP 400ml
    Prothrombin complex concentrate
    Recombinant factor VII<\/td><\/tr>
    Hirudin<\/td>Desmopressin\/DDAVP
    Recombinant factor VII<\/td><\/tr>
    Xarelto<\/td>Prothrombin complex concentrate
    Activated prothrombin complex concentrate
    Recombinant factor VII<\/td><\/tr>
    Pradaxa<\/td>Pradaxbind=idarucizumab<\/td><\/tr>
    Aspirin<\/td>Desmopressin
    Platelet concentrate<\/td><\/tr>
    Clopidogrel<\/td>Platelet concentrate<\/td><\/tr>
    GPIIb\/IIIa antagonist<\/td>Platelet concentrate<\/td><\/tr>
    SK, UK, rtPA<\/td>FFP
    Platelet concentrate
    Exacyl injection<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n<\/span>\n

    Frequency of bleeding<\/h4>\n<\/span>\n\n\n
    \"\"<\/figure>\n\n\n\n

    For coumarol, at INR over 3 the frequency starts to increase dramatically, over 7 is is >200%\/yr.<\/p>\n\n\n\n

    \"\"<\/figure>\n<\/span>

    Antithrombotics<\/h4>

    Labratory tests<\/h4>

    Antidotes<\/h4>

    Frequency of bleeding<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

    Antithrombotics Anticoagulants (UFH, LMWH, coumarin, Xarelto=Rivaroxaban, Pradaxa=Dabigatran) Antiplatelets (ASA, clopidogrel, GPIIb\/IIIa blocking agents=Abciximab) Thrombolytics (Streptokinase=SK, rtPA=Actilyse) Labratory tests Antidotes Antithrombotic Antidote Heparin (UFH) Protamine sulfate (1-2ml iv.) LMWH Protamine sulfate (>30%) Coumarol Vit K injection 1.25-10mgFFP 400mlProthrombin complex concentrateRecombinant factor VII Hirudin Desmopressin\/DDAVPRecombinant factor VII Xarelto Prothrombin complex concentrateActivated prothrombin complex concentrateRecombinant factor VII Pradaxa […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5575,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5797","page","type-page","status-publish","hentry"],"yoast_head":"\nAntidotes to antithrombotics – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/thrombocytopenia-and-platelet-disorders\/antidotes-to-antithrombotics\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" 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