{"id":5619,"date":"2021-05-21T01:56:46","date_gmt":"2021-05-20T23:56:46","guid":{"rendered":"https:\/\/meddists.com\/learn\/clinical\/hematology\/thrombocytopenia-and-platelet-disorders\/acquired-thrombophilia\/"},"modified":"2022-01-01T21:29:40","modified_gmt":"2022-01-01T19:29:40","slug":"acquired-thrombophilia","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/thrombocytopenia-and-platelet-disorders\/acquired-thrombophilia\/","title":{"rendered":"Acquired thrombophilia"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Acquired thrombophilia includes conditions that lead to thrombophilia but are not congenital.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Hospital-acquired (HAT)<\/strong><ul><li>Thrombosis occurring within 90 days of hospitalization<\/li><li>Postoperative and in prolonged bed rest<\/li><li>Anesthesia<\/li><li>Thromboprophylaxis and risk assessment are used for prevention.<\/li><\/ul><\/li><li><strong>Malignancy<\/strong><ul><li>Trousseau&#8217;s syndrome: increased cases of thrombosis in certain types of malignancies, such as pancreatic and lung cancer.<\/li><li>Tumors producing tissue factor and lyse endogenous heparan sulfate.<\/li><li>Mucin\u2010secreting adenocarcinomas may be associated with DIC.<\/li><\/ul><\/li><li><strong>Inflammation, autoimmune, injury<\/strong><ul><li>Inflammation up\u2010regulates procoagulant factors and down\u2010regulates anticoagulant pathways, particularly protein C.<\/li><li>Antiphospholipid syndrome<\/li><li>Venous injury in case of traumatic venesection.<\/li><li>Vasculitides (Buerger&#8217;s, and Beh\u00e7et\u2019s disease)<\/li><\/ul><\/li><li><strong>Blood disorders and other conditions<\/strong><ul><li>MDS<\/li><li>ET<\/li><li>PNH<\/li><li>AF<\/li><li>Paraproteins<\/li><li>Post-splenectomy during thrombocytosis (in sickle-cell disease)<\/li><\/ul><\/li><li><strong>Estrogen therapy<\/strong><ul><li>Associated with elevated levels of clotting factors.<\/li><\/ul><\/li><li><strong>Venous stasis and immobility<\/strong><ul><li>Flights, long sitting<\/li><\/ul><\/li><\/ul>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Antiphospholipid syndrome (APS)<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">The antiphospholipid antibody syndrome (APS) is an autoimmune disorder that consists of thrombosis and loss of pregnancy caused by various antibodies directed against one or more phospholipid-bound proteins (beta-2 glycoprotein-1, prothrombin, annexin A5). <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Diagnosis:<\/strong><ul><li>APTT is prolonged (because the autoantibodies interfere with coagulation factor assembly and activation) and does not shorten in mixing studies<\/li><li>Serology to confirm<\/li><\/ul><\/li><li><strong>Treatment:<\/strong> <ul><li>Aspirin, heparin, warfarin<\/li><\/ul><\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Clinical manifestation<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<ul class=\"wp-block-list\"><li>Arterial thrombus: the limb is pale, cold, with a weak pulse.<ul><li>Can come on its own or from a DVT embolism in patent foramen ovale (paradoxical embolism).<\/li><\/ul><\/li><li>Venous thrombus: the limb is purple\/dark blue, warm, with a pulse.<ul><li>Most commonly, in the lower limb.<\/li><\/ul><\/li><\/ul>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Antiphospholipid syndrome (APS)<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Clinical manifestation<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>Acquired thrombophilia includes conditions that lead to thrombophilia but are not congenital. Hospital-acquired (HAT) Thrombosis occurring within 90 days of hospitalization Postoperative and in prolonged bed rest Anesthesia Thromboprophylaxis and risk assessment are used for prevention. Malignancy Trousseau&#8217;s syndrome: increased cases of thrombosis in certain types of malignancies, such as pancreatic and lung cancer. Tumors [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5575,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5619","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Acquired thrombophilia &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/thrombocytopenia-and-platelet-disorders\/acquired-thrombophilia\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/clinical\\\/internal-medicine\\\/hematology\\\/thrombocytopenia-and-platelet-disorders\\\/acquired-thrombophilia\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/clinical\\\/internal-medicine\\\/hematology\\\/thrombocytopenia-and-platelet-disorders\\\/acquired-thrombophilia\\\/\",\"name\":\"Acquired thrombophilia &#8211; 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