{"id":5353,"date":"2021-05-15T23:53:42","date_gmt":"2021-05-15T21:53:42","guid":{"rendered":"https:\/\/meddists.com\/learn\/clinical\/hematology\/hematological-oncology\/indolent-lymphomas-follicular-malt-hairy-cell\/"},"modified":"2021-05-27T15:30:18","modified_gmt":"2021-05-27T13:30:18","slug":"indolent-lymphomas-follicular-malt-hairy-cell","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/oncological-disorders\/lymphomas\/indolent-lymphomas-follicular-malt-hairy-cell\/","title":{"rendered":"Indolent lymphomas (follicular, MALT, hairy-cell)"},"content":{"rendered":"\n

Make sure you cover the lymphomas<\/a> article first.<\/em><\/p>\n\n\n\n

Indolent lymphomas are those lymphomas that are slow-growing and progressing, but they are generally considered incurable.<\/div><\/p>\n\n\n\n
  • They include:
    • CLL\/SLL<\/li>
    • Follicular lymphoma<\/li><\/ul>
      • Marginal zone lymphoma<\/li><\/ul><\/li>
      • Generally, treatments include:
        • CHOP +- R<\/li>
        • CVP +- R<\/li><\/ul><\/li><\/ul>\n\n\n\n

          Follicular lymphoma<\/h4>\n<\/span>\n\n\n

          Follicular lymphoma is B-cell lymphoma found in the germinal center.<\/p>\n\n\n\n

          • 2nd-most common NHL, appearing in older adult smokers.<\/li>
          • Histologically, the entire lymph node is packed full of lymphoid follicles (occupying the medulla as well); graded I-III based on the number of centrocytes<\/strong> and centroblasts<\/strong>.<\/li>
          • Associated with t(14;18) with BCL2 overexpression.<\/li>
          • Presents with painless lymph node enlargement.<\/li>
          • Can progress to DLBCL.<\/li>
          • Treatment:
            • First line: R-CVP, R-CHOP, R-benda, R, G-benda<\/li>
            • Maintenance: R alone<\/li><\/ul><\/li><\/ul>\n\n\n<\/span>\n

              MALT lymphoma<\/h4>\n<\/span>\n\n\n

              MALT lymphoma is a type of extranodal marginal zone lymphoma<\/strong> arising in the mucosal tissues. <\/p>\n\n\n\n

              • It resembles the mucosa-associated lymphatic tissue (hence the name).<\/li>
              • It is thought to arise as lymphocyte hyperplasia due to chronic inflammation, undergoing oncological genetic changes (most often of the stomach caused by H. pylori).<\/li>
              • In the stomach, it appears similar to a gastric ulcer and behaves in a similar way (bleeding).<\/li>
              • Treatment includes eradication of the cause of inflammation and R-CHOP<\/strong> to treat the lymphoma.
                • Treatment for H. pylori: amoxicillin, clarithromycin, metronidazole, and omeprazole.<\/li><\/ul><\/li><\/ul>\n\n\n<\/span>\n

                  Hairy-cell leukemia<\/h4>\n<\/span>\n\n\n

                  Hairy-cell leukemia is a rare form of an indolent B-cell lymphoproliferative disorder that is typically classified under CLL. <\/p>\n\n\n\n

                  • Thought to arise from memory B cells of the marginal zone; has similar characteristics to MZL.<\/li>
                  • The cells have hairlike (“hairy”) cytoplasmic projections; relatively exclusive surface markers include CD11c and CD103.<\/li>
                  • Presents with hepatosplenomegaly, bone marrow infiltration, and monocytopenia, but typically without lymph node enlargement.<\/li>
                  • Presents with BRAF mutation.<\/li>
                  • Extremely sensitive to chemotherapy; excellent prognosis.<\/li>
                  • Treatment includes rituximab + cladribine or pentostatin.<\/li><\/ul>\n<\/span>

                    Follicular lymphoma<\/h4>

                    MALT lymphoma<\/h4>

                    Hairy-cell leukemia<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

                    Make sure you cover the lymphomas article first. They include: CLL\/SLL Follicular lymphoma Marginal zone lymphoma Generally, treatments include: CHOP +- R CVP +- R Follicular lymphoma Follicular lymphoma is B-cell lymphoma found in the germinal center. 2nd-most common NHL, appearing in older adult smokers. Histologically, the entire lymph node is packed full of lymphoid […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5478,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5353","page","type-page","status-publish","hentry"],"yoast_head":"\nIndolent lymphomas (follicular, MALT, hairy-cell) – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/oncological-disorders\/lymphomas\/indolent-lymphomas-follicular-malt-hairy-cell\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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