{"id":3052,"date":"2020-12-13T21:22:39","date_gmt":"2020-12-13T19:22:39","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/neurohistology\/cerebellum\/fibers-of-the-cerebellum\/"},"modified":"2022-07-30T22:50:54","modified_gmt":"2022-07-30T20:50:54","slug":"fibers-of-the-cerebellum","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/nervous-system\/cerebellum\/fibers-of-the-cerebellum\/","title":{"rendered":"Fibers of the Cerebellum"},"content":{"rendered":"
\n
\"\"<\/a>
Figure 1. <\/strong>Schematic drawing of the fibers in the cerebellum\u00a0<\/strong>—\u00a0Haphip — CC BY-SA 3.0<\/figcaption><\/figure>\n<\/div>\n\n\n

Reminder — in the cerebellum, all of the neurons except for granule cells<\/strong> (that means stellate, basket, Golgi, Purkinje, and Lugaro cells (not shown above)) are considered inhibitory <\/strong>– meaning, they contain inhibitory synapses at the end of their axons, and they use inhibitory neurotransmitters such as GABA<\/strong> (Purkinje cells).<\/p>\n\n\n\n

Granule cells are therefore considered excitatory and use excitatory neurotransmitters (Glutamate).<\/p>\n\n\n\n

In essence, when we talk about the fibers of the cerebellum<\/strong>, we mean the axon of groups of cells that have an excitatory or inhibitory effect on other cells.<\/p>\n\n\n\n

  • Purkinje cells provide the efferent fibers<\/strong> of the cerebellum — they are considered to be the “working horse” of the cerebellum
    • Purkinje cells send efferent inhibitory fibers to the deep cerebellar<\/strong> nuclei <\/strong>and are responsible for the sole output of motor coordination from the cerebellar cortex<\/li>
    • Most of the fibers in the cerebellum are either directly or indirectly responsible for the activation or inhibition of Purkinje cells<\/li><\/ul><\/li>
    • The fibers can come from within the cerebellum<\/strong> (they’re all inhibitory except for Granule cells — Parallel fibers), while fibers coming from outside of the cerebellum<\/strong> are usually excitatory (mossy<\/strong> and climbing fibers<\/strong>)<\/li><\/ul>\n\n\n\n

      Molecular layer<\/h3>\n<\/span>\n\n<\/span>\n

      Collateral axons<\/h4>\n<\/span>\n\n\n
      • Efferent fibers originating from basket cells<\/strong>, forming inhibitory synapses on the Purkinje cells
        • Hence, their activation (excitation) will inhibit the Purkinje cells<\/li><\/ul><\/li>
        • Their fibers surround the Purkinje cell soma (body) and form a basket-like engulfment (hence the name)<\/li><\/ul>\n\n\n<\/span>\n

          Climbing fibers<\/h4>\n<\/span>\n\n\n
          • Form the o<\/strong>livocerebellar tract<\/strong><\/li>
          • Originate from the inferior olives<\/li>
          • Form excitatory synapses on the Purkinje cells
            • Hence, their activation will activate the Purkinje cells<\/li><\/ul><\/li><\/ul>\n\n\n<\/span>\n

              Parallel fibers<\/h4>\n<\/span>\n\n\n
              • Originate from the Granule cells (Granular layer)<\/li>
              • Form excitatory synapses on the Purkinje cells.<\/li><\/ul>\n\n\n<\/span>\n

                Granular layer<\/h3>\n<\/span>\n\n<\/span>\n

                Mossy fibers<\/h4>\n<\/span>\n\n\n
                • Originate from cells located in many nuclei throughout the brainstem and spinal cord — To name a few:
                  • Spinal cord as the s<\/strong>p<\/strong>inocerebellar tract<\/strong><\/li>
                  • Vestibular nuclei as the v<\/strong>estibulocerebellar tract<\/strong><\/li>
                  • Pons as the pontocerebellar tract<\/strong><\/li><\/ul><\/li><\/ul>\n\n\n<\/span>\n

                    Cerebellar glomeruli<\/h4>\n<\/span>\n\n\n

                    These are not fibers per se, but rather oval areas which are nucleus-free with eosinophilic staining, also known as complex synaptic structures. Cerebellar glomeruli are composed of:<\/p>\n\n\n\n

                    • Afferent Mossy fiber<\/strong> \u2013 Central component<\/li>
                    • Granule cell dendrites<\/strong><\/li>
                    • Golgi cell dendrites and axons<\/strong><\/li><\/ul>\n<\/span>

                      Molecular layer<\/h3>

                      Collateral axons<\/h4>

                      Climbing fibers<\/h4>

                      Parallel fibers<\/h4>

                      Granular layer<\/h3>

                      Mossy fibers<\/h4>

                      Cerebellar glomeruli<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

                      Reminder — in the cerebellum, all of the neurons except for granule cells (that means stellate, basket, Golgi, Purkinje, and Lugaro cells (not shown above)) are considered inhibitory – meaning, they contain inhibitory synapses at the end of their axons, and they use inhibitory neurotransmitters such as GABA (Purkinje cells). Granule cells are therefore considered excitatory […]<\/p>\n","protected":false},"author":23,"featured_media":0,"parent":3030,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3052","page","type-page","status-publish","hentry"],"yoast_head":"\nFibers of the Cerebellum – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/nervous-system\/cerebellum\/fibers-of-the-cerebellum\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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