{"id":3045,"date":"2020-12-13T21:20:18","date_gmt":"2020-12-13T19:20:18","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/neurohistology\/introduction\/the-blood-brain-barrier\/"},"modified":"2020-12-13T21:55:36","modified_gmt":"2020-12-13T19:55:36","slug":"the-blood-brain-barrier","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/nervous-system\/introduction\/the-blood-brain-barrier\/","title":{"rendered":"The Blood-Brain Barrier"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/meddists.com\/wp-content\/uploads\/2019\/01\/bbb1.jpg\" target=\"_blank\" title=\"The Blood-Brain Barrier\"><img decoding=\"async\" src=\"http:\/\/meddists.com\/wp-content\/uploads\/2019\/01\/bbb1-600x371.jpg\" alt=\"\" class=\"wp-image-8842\"\/><\/a><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The structure of the blood-brain barrier<\/strong>&nbsp;&#8212; Adapted from the work of Armin K\u00fcbelbeck &#8212; CC BY-SA 4.0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The brain is arguably the most sensitive organ of the human body &#8212; the slightest disruption of homeostasis can lead to massive disruption of the neuronal cells &#8212; therefore, we must protect it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The blood-brain barrier develops during early embryological development<\/li><li>It is<strong> formed by tight junctions of the endothelial cells of blood vessels<\/strong> and maintained by astrocytes, permitting the passage of molecules with the size of <strong>less than 500 Dalton<\/strong><\/li><li>The blood-brain barrier also helps <strong>prevent loss of potassium<\/strong>, which is crucial to the functionality of neurons<\/li><li>Certain molecules such as steroids and ethanol, pass through the barrier freely<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">However, not all of the brain is protected by this barrier. Certain structures (specifically those bordering the 3rd and 4th ventricles) are called the &#8220;windows of the brain&#8221;, allow direct contact with all of the blood components. It is hypothesized that their function is sampling.<\/p>\n<div id=\"the_titles\" style=\"display:none;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>The structure of the blood-brain barrier&nbsp;&#8212; Adapted from the work of Armin K\u00fcbelbeck &#8212; CC BY-SA 4.0 The brain is arguably the most sensitive organ of the human body &#8212; the slightest disruption of homeostasis can lead to massive disruption of the neuronal cells &#8212; therefore, we must protect it. The blood-brain barrier develops during [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":0,"parent":3028,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3045","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Blood-Brain Barrier &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/nervous-system\/introduction\/the-blood-brain-barrier\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/histology\\\/nervous-system\\\/introduction\\\/the-blood-brain-barrier\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/histology\\\/nervous-system\\\/introduction\\\/the-blood-brain-barrier\\\/\",\"name\":\"The Blood-Brain Barrier &#8211; 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