{"id":3042,"date":"2020-12-13T21:20:17","date_gmt":"2020-12-13T19:20:17","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/neurohistology\/introduction\/myelin\/"},"modified":"2021-12-11T13:47:06","modified_gmt":"2021-12-11T11:47:06","slug":"myelin","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/nervous-system\/introduction\/myelin\/","title":{"rendered":"Myelin"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><div class=\"intro\">Myelin is an insulator sheath for nerve axons. It is composed of phospholipid lamellae, and offers isolation to the axons, ensuring rapid conduction of nerve impulses.<\/div><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/meddists.com\/wp-content\/uploads\/2018\/02\/myelin.jpg\" target=\"_blank\" title=\"Myelin\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"http:\/\/meddists.com\/wp-content\/uploads\/2018\/02\/myelin.jpg\" alt=\"\" class=\"wp-image-1375\"\/><\/a><figcaption><strong>Figure 1.<strong> The structure of a myelinated axon<\/strong><\/strong><\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Axons can be either covered by myelin (<strong>myelinated<\/strong>) or bare (<strong>unmyelinated<\/strong>). Myelin is found in both the CNS and PNS; however, its composition and means of production are different. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Myelin sheaths are not continuous. They contain gaps which are called <strong>nodes of Ranvier<\/strong> (seen above)<\/p>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Myelin in the PNS and CNS<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">Both in the PNS and CNS, myelin is produced by special supporting cells belonging to the family of <strong>neuroglial cells<\/strong>.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Neuroglial cells are the name of a group of cells that support the neurons. They are different in the PNS and CNS (more about neuroglial cells in the following articles).<\/li><li>In the PNS, myelin is produced by neuroglial cells called <strong>Schwann cells<\/strong>, while in the CNS its being produced by<strong> Oligodendrocytes<\/strong>.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">We&#8217;ll cover the myelination process and differences in each of the neuroglial articles.<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Conduction<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">Nerve conduction can be either <strong>continuous<\/strong> (river-like flow of action potential across the cell membrane), as the classical type we&#8217;ve all been taught in high-school biology, or <strong>saltatory<\/strong> (&#8220;jumping&#8221;) conduction.<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Saltatory conduction<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<p class=\"wp-block-paragraph\">In axons containing myelin sheaths, the action potential only occurs in the nodes of Ranvier &#8212; where the axon membrane is exposed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is preferable impulse conduction, since the signal travels much faster, because the action potential only happens in segments, without having to depolarize and repolarize the entire cell membrane.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/meddists.com\/wp-content\/uploads\/2019\/01\/Saltatory_Conduction1.gif\" target=\"_blank\" title=\"Myelin\"><img decoding=\"async\" src=\"http:\/\/meddists.com\/wp-content\/uploads\/2019\/01\/Saltatory_Conduction1.gif\" alt=\"\" class=\"wp-image-8543\"\/><\/a><figcaption><strong>Figure 2. <strong>Continuous (left) vs saltatory (right) conduction<\/strong><\/strong><\/figcaption><\/figure><\/div>\n\n\n<\/span><span class=\"block-heading\" id=\"header_4\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Demonstration<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_4\">\n\n\n<p class=\"wp-block-paragraph\">Generally, the myelin sheath cannot be seen by regular H&amp;E staining; therefore, we must use heavy metal impregnation, for example, <strong>osmium tetroxide<\/strong>,&nbsp;to impregnate the phospholipid lamellas of the myelin sheath.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"http:\/\/meddists.com\/wp-content\/uploads\/2019\/01\/Myelinated_neuron1.jpg\" target=\"_blank\" title=\"Myelin\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"http:\/\/meddists.com\/wp-content\/uploads\/2019\/01\/Myelinated_neuron1-300x300.jpg\" alt=\"\" class=\"wp-image-8578\"\/><\/a><figcaption> <strong>Figure 3. Myelinated axon <\/strong>(electron microscope)<\/figcaption><\/figure><\/div>\n\n\n<\/span><span class=\"block-heading\" id=\"header_5\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">References<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_5\">\n\n\n<ol class=\"wp-block-list\"><li><strong>Figure 1. <\/strong>OpenStax, Anatomy and Physiology. CC BY-SA 4.0<\/li><li><strong>Figure 2. <\/strong>Dr. Jana. CC BY-SA 4.0<\/li><\/ol>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Myelin in the PNS and CNS<\/h3><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Conduction<\/h3><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Saltatory conduction<\/h4><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Demonstration<\/h3><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">References<\/h3><\/div>","protected":false},"excerpt":{"rendered":"<p>Axons can be either covered by myelin (myelinated) or bare (unmyelinated). Myelin is found in both the CNS and PNS; however, its composition and means of production are different. Myelin sheaths are not continuous. They contain gaps which are called nodes of Ranvier (seen above) Myelin in the PNS and CNS Both in the PNS [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":0,"parent":3028,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3042","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Myelin &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/histology\/nervous-system\/introduction\/myelin\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/histology\\\/nervous-system\\\/introduction\\\/myelin\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/histology\\\/nervous-system\\\/introduction\\\/myelin\\\/\",\"name\":\"Myelin &#8211; 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