{"id":2388,"date":"2020-09-21T13:19:21","date_gmt":"2020-09-21T11:19:21","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/cell-proliferation-and-apoptosis\/biochemical-interpretation-of-the-cell-cycle-the-function-of-g2-m-phase-kinase\/"},"modified":"2020-09-21T13:21:50","modified_gmt":"2020-09-21T11:21:50","slug":"biochemical-interpretation-of-the-cell-cycle-the-function-of-g2-m-phase-kinase","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/cell-proliferation-and-apoptosis\/biochemical-interpretation-of-the-cell-cycle-the-function-of-g2-m-phase-kinase\/","title":{"rendered":"Biochemical interpretation of the cell cycle. The function of G2 \u2013 M phase kinase"},"content":{"rendered":"\n

After biochemical changes in S phase (copying of DNA, histone synthesis)<\/h4>\n<\/span>\n\n\n
  1. The cell enters G2 state<\/li>
  2. The cell prepares itself for mitosis and controls S phase<\/li>
  3. Until the cell cycle passes from G->M until all is controlled<\/li>
  4. The regulation of the M phase kinase occurs via CDC2\/CDK1<\/li><\/ol>\n\n\n<\/span>\n

    This complex (M phase kinase) with cyclin B<\/h4>\n<\/span>\n\n\n
    1. It is inactive in phase G2 because it is phosphorylated at the ATP binding site (has a total of 3 phosphates)<\/li>
    2. Two inhibitory and one activator phosphates are there<\/li>
    3. Normally, the CDK1 is inhibited by the CKI<\/li>
    4. After the presence of cyclin-B, the inhibitor is released from the CDK1, but it is still not active<\/li>
    5. In the presence of cdc25 phosphatase, the THR and TYR side chains are dephosphorylated<\/li>
    6. Thereby activating the CDK1-cyclin B complex with the remaining activating phosphate<\/li>
    7. It catalyzes mitotic events up to point M (substrates H1 histone, laminae, cytoskeletal protein, centrosome)<\/li>
    8. Mitosis anaphase promoter complex (APC) appears<\/li>
    9. APC initiates CYCLIN-B release and phosphate re-release<\/li>
    10. The complex is inactivated and the progress is going further for the next cell cycle stage<\/li><\/ol>\n\n\n\n
      \"\"<\/a><\/figure><\/div>\n\n\n\n

      Figure 1. CDC25 (G2-M kinase) acting with\u00a0 cyclin-B<\/strong><\/p>\n<\/span>

      After biochemical changes in S phase (copying of DNA, histone synthesis)<\/h4>

      This complex (M phase kinase) with cyclin B<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

      After biochemical changes in S phase (copying of DNA, histone synthesis) The cell enters G2 state The cell prepares itself for mitosis and controls S phase Until the cell cycle passes from G->M until all is controlled The regulation of the M phase kinase occurs via CDC2\/CDK1 This complex (M phase kinase) with cyclin B […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2333,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2388","page","type-page","status-publish","hentry"],"yoast_head":"\nBiochemical interpretation of the cell cycle. 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