{"id":2377,"date":"2020-09-21T13:12:41","date_gmt":"2020-09-21T11:12:41","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/signal-transduction\/cgmp-pathway-soluble-version\/"},"modified":"2020-09-21T13:16:56","modified_gmt":"2020-09-21T11:16:56","slug":"cgmp-pathway-soluble-version","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/signal-transduction\/cgmp-pathway-soluble-version\/","title":{"rendered":"cGMP pathway \u2014 soluble version"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>Soluble guanylate cyclases pathway and its reactions occur in smooth muscle and endothelial cells.<\/em><\/p>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Steps of production of cGMP (Figure 1)<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ol class=\"wp-block-list\"><li>In order to become active, a ligand must activate the 7-TM receptor and cause a conformational change<\/li><li>This conformational change causes the alpha subunit to dissociate from the complex and become bound to GTP (GUANINE EXCHANGE FACTOR reaction)<\/li><li>This G-alpha-GTP complex then binds to guanylate cyclase and causes the release of cGMP, followed by the activation of several enzymes<\/li><li>The deactivation of the active G-alpha-GTP complex occur rapidly by GTP hydrolysis triggered by the intrinsic enzymatic activity of GTPase located in the alpha subunit (GAP \u2014 GTPase reaction)<\/li><li>ACH can activate the pathway by enhancing the Ca-ion influx<\/li><li>The enhanced level of the calcium ions activates the NO synthase enzymes in the endothelium<\/li><li>In smooth muscle cells, NO activates the soluble Guanylate cyclases and the level of cGMP results vasodilation<\/li><li>While the activation of the cGMP phosphodiesterase activity increases the level of the cGMP is decreasing.<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_25903\"><a href=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/03\/17310970_1237659486340885_7144912244107513475_o.jpg\" target=\"_blank\" title=\"cGMP pathway \u2014 soluble version\"><img decoding=\"async\" src=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/03\/17310970_1237659486340885_7144912244107513475_o-1011x1024.jpg\" alt=\"\" class=\"wp-image-25903\"\/><\/a><figcaption><strong>Figure 1. cGMP pathway (soluble version)<\/strong><\/figcaption><\/figure>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Steps of production of cGMP (Figure 1)<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>Soluble guanylate cyclases pathway and its reactions occur in smooth muscle and endothelial cells. Steps of production of cGMP (Figure 1) In order to become active, a ligand must activate the 7-TM receptor and cause a conformational change This conformational change causes the alpha subunit to dissociate from the complex and become bound to GTP [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2332,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2377","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>cGMP pathway \u2014 soluble version &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/signal-transduction\/cgmp-pathway-soluble-version\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/signal-transduction\\\/cgmp-pathway-soluble-version\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/signal-transduction\\\/cgmp-pathway-soluble-version\\\/\",\"name\":\"cGMP pathway \u2014 soluble version &#8211; 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