{"id":2375,"date":"2020-09-21T13:12:40","date_gmt":"2020-09-21T11:12:40","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/signal-transduction\/adenylate-cyclase-camp-pathway\/"},"modified":"2020-09-21T13:15:54","modified_gmt":"2020-09-21T11:15:54","slug":"adenylate-cyclase-camp-pathway","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/signal-transduction\/adenylate-cyclase-camp-pathway\/","title":{"rendered":"Adenylate Cyclase \u2014 cAMP Pathway"},"content":{"rendered":"<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Steps of cAMP production (Figure 1)<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ol class=\"wp-block-list\"><li>G-proteins can be found in the heterotrimeric form, consisting of three subunits (alpha, beta, gamma)<\/li><li>With GDP bound to the alpha subunit, the G protein is inactive<\/li><li>In order to become active, a ligand must bind to the 7-TM receptor and cause a conformational change<\/li><li>This conformational change causes the alpha subunit to dissociate from the complex and become bound to GTP (GUANINE EXCHANGE FACTOR reaction)<\/li><li>This G-alpha-GTP complex then binds to adenylate cyclase and causes the release of cAMP, followed by the activation of several enzymes<\/li><li>The deactivation of the active G-alpha-GTP complex occurs rapidly by GTP hydrolysis triggered by the intrinsic enzymatic activity of GTPase located in the alpha subunit (GAP- GTPase reaction).<\/li><\/ol>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_25893\"><a href=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/03\/ADENILATE-CYCLASE.jpg\" target=\"_blank\" title=\"Adenylate Cyclase \u2014 cAMP Pathway\"><img decoding=\"async\" src=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/03\/ADENILATE-CYCLASE-1024x427.jpg\" alt=\"\" class=\"wp-image-25893\"\/><\/a><figcaption><strong>Figure 1. cAMP pathway<\/strong><\/figcaption><\/figure>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Steps of cAMP production (Figure 1)<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>Steps of cAMP production (Figure 1) G-proteins can be found in the heterotrimeric form, consisting of three subunits (alpha, beta, gamma) With GDP bound to the alpha subunit, the G protein is inactive In order to become active, a ligand must bind to the 7-TM receptor and cause a conformational change This conformational change causes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2332,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2375","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Adenylate Cyclase \u2014 cAMP Pathway &#8211; 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