{"id":2374,"date":"2020-09-21T13:12:39","date_gmt":"2020-09-21T11:12:39","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/signal-transduction\/7-tm-receptors\/"},"modified":"2020-09-21T13:15:21","modified_gmt":"2020-09-21T11:15:21","slug":"7-tm-receptors","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/signal-transduction\/7-tm-receptors\/","title":{"rendered":"7-TM receptors"},"content":{"rendered":"<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">7-transmembrane receptors (Figure 1)<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ul class=\"wp-block-list\"><li>Seven transmembrane domains.<\/li><li>N-terminal region:&nbsp; N-linked oligosaccharides\/extracellular side.<\/li><li>C-terminal region: serine\/threonine sites for reversible phosphorylation.<\/li><li>The 3rd domain recognizes the G protein.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_24935\"><a href=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/02\/7-TM.jpg\" target=\"_blank\" title=\"7-TM receptors\"><img decoding=\"async\" src=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/02\/7-TM-1024x427.jpg\" alt=\"\" class=\"wp-image-24935\"\/><\/a><figcaption><strong>Figure 1. 3D representation of a 7-TM receptor based on the PDB data<\/strong>&nbsp;(https:\/\/www.rcsb.org\/structure\/4JKV)<\/figcaption><\/figure>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">ACT of 7-TM receptors via G proteins (Figure 2)<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<ul class=\"wp-block-list\"><li>Ligands that activate these receptors include:<ul><li>Light-sensitive compounds<\/li><li>Odors<\/li><li>Pheromones<\/li><li>Hormones<\/li><li>Neurotransmitters.<\/li><\/ul><\/li><li>Signal transduction pathways involving the G protein-coupled receptors are:<ul><li>The cAMP signal pathway<\/li><li>The phosphatidylinositol signal pathway.<\/li><\/ul><\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_24940\"><a href=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/02\/G-proteins.jpg\" target=\"_blank\" title=\"7-TM receptors\"><img decoding=\"async\" src=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/02\/G-proteins-1024x426.jpg\" alt=\"\" class=\"wp-image-24940\"\/><\/a><figcaption><strong>Figure 2.&nbsp; 7-TM receptor and G proteins<\/strong><\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_24932\"><a href=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/02\/Signaling-big-picture.jpg\" target=\"_blank\" title=\"7-TM receptors\"><img decoding=\"async\" src=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/02\/Signaling-big-picture-1024x769.jpg\" alt=\"\" class=\"wp-image-24932\"\/><\/a><figcaption><strong>Table 1. Classification of the reactions regarding the receptors<\/strong><\/figcaption><\/figure>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">7-transmembrane receptors (Figure 1)<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">ACT of 7-TM receptors via G proteins (Figure 2)<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>7-transmembrane receptors (Figure 1) Seven transmembrane domains. N-terminal region:&nbsp; N-linked oligosaccharides\/extracellular side. C-terminal region: serine\/threonine sites for reversible phosphorylation. The 3rd domain recognizes the G protein. ACT of 7-TM receptors via G proteins (Figure 2) Ligands that activate these receptors include: Light-sensitive compounds Odors Pheromones Hormones Neurotransmitters. Signal transduction pathways involving the G protein-coupled receptors [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2332,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2374","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>7-TM receptors &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/signal-transduction\/7-tm-receptors\/\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/signal-transduction\\\/7-tm-receptors\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/signal-transduction\\\/7-tm-receptors\\\/\",\"name\":\"7-TM receptors &#8211; 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