{"id":2340,"date":"2020-09-21T12:18:22","date_gmt":"2020-09-21T10:18:22","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/sports-biochemistry\/chronic-effects-of-exercise\/"},"modified":"2020-09-21T12:48:36","modified_gmt":"2020-09-21T10:48:36","slug":"chronic-effects-of-exercise","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/","title":{"rendered":"Chronic effects of exercise"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>In muscle, liver and adipose tissue, the chronic effects of exercise are similar to the autophagy based acute effects.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The basal activity of AMP-kinase is increased due to endurance training with:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Increased insulin sensitivity.<\/li><li>Increased rate of fatty acid oxidation.<\/li><li>Decreased activity of enzymes involved in lipid synthesis (ACC).<\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Interaction between exercise-induced Master Regulators:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>AMPK<\/li><li>SIRT1 (utilizes NAD<sup>+<\/sup>as co-substrate transferring acetyl group from proteins to NAD<sup>+&nbsp;<\/sup>producing Nicotinamide (NAM) and acetylated ADP-ribose).<\/li><li>PGC1\u03b1<\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">The energy state of the cell is reflected by the level of NAD+affecting the activity of SIRT1. Exercise and caloric restriction activates AMPK and SIRT1.<\/p>\n<div id=\"the_titles\" style=\"display:none;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>In muscle, liver and adipose tissue, the chronic effects of exercise are similar to the autophagy based acute effects. The basal activity of AMP-kinase is increased due to endurance training with: Increased insulin sensitivity. Increased rate of fatty acid oxidation. Decreased activity of enzymes involved in lipid synthesis (ACC). Interaction between exercise-induced Master Regulators: AMPK [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":278,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2340","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chronic effects of exercise &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/sports-biochemistry\\\/chronic-effects-of-exercise\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/sports-biochemistry\\\/chronic-effects-of-exercise\\\/\",\"name\":\"Chronic effects of exercise &#8211; 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Meddists","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/","url":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/","name":"Chronic effects of exercise &#8211; Meddists","isPartOf":{"@id":"https:\/\/meddists.com\/learn\/#website"},"datePublished":"2020-09-21T10:18:22+00:00","dateModified":"2020-09-21T10:48:36+00:00","breadcrumb":{"@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/chronic-effects-of-exercise\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/meddists.com\/learn\/"},{"@type":"ListItem","position":2,"name":"Pre-clinical","item":"https:\/\/meddists.com\/learn\/pre-clinical\/"},{"@type":"ListItem","position":3,"name":"Biochemistry","item":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/"},{"@type":"ListItem","position":4,"name":"Biochemistry of the tissues","item":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/"},{"@type":"ListItem","position":5,"name":"Sports Biochemistry","item":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/"},{"@type":"ListItem","position":6,"name":"Chronic effects of exercise"}]},{"@type":"WebSite","@id":"https:\/\/meddists.com\/learn\/#website","url":"https:\/\/meddists.com\/learn\/","name":"Meddists","description":"Let&#039;s Get Studying","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/meddists.com\/learn\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/2340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/comments?post=2340"}],"version-history":[{"count":1,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/2340\/revisions"}],"predecessor-version":[{"id":2352,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/2340\/revisions\/2352"}],"up":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/278"}],"wp:attachment":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/media?parent=2340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}