{"id":2337,"date":"2020-09-21T12:18:21","date_gmt":"2020-09-21T10:18:21","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/sports-biochemistry\/effect-of-exercise-on-the-metabolism-of-fatty-acids\/"},"modified":"2020-09-21T12:39:20","modified_gmt":"2020-09-21T10:39:20","slug":"effect-of-exercise-on-the-metabolism-of-fatty-acids","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/effect-of-exercise-on-the-metabolism-of-fatty-acids\/","title":{"rendered":"Effect of exercise on the metabolism of fatty acids"},"content":{"rendered":"<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Basic effects of exercise on the metabolism of fatty acids<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ol class=\"wp-block-list\"><li>AMPK is activated<\/li><li>AMPK phosphorylates and inactivates the Acetyl-CoA carboxylase\u00a0(Synthesis of Malonyl-CoA)<\/li><li>Malonyl-Coa level decreases<\/li><li>CPT1 inhibition disappears<\/li><li>The transport of the fatty acid into the mitochondria and the rate of \u03b2-oxidation is increased<\/li><li>AMPK also phosphorylates glycerol-3-phosphate acyltransferase<\/li><li>TAG synthesis is inhibited.<\/li><\/ol>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Gene expression effects of exercise on the metabolism<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">PGC1-\u03b1<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<ul class=\"wp-block-list\"><li>It is a transcriptional coactivator.<\/li><li>Its expression is increased by physical activity.<\/li><li>It is a co-activator, docking to transcription factors.<\/li><li>Providing a platform for the recruitment of regulatory protein complexes.<\/li><li>Physical activity increases the amount of active PGC1\u03b1 in muscle.<\/li><li>Exercised induced overexpression of PGC1\u03b1 increases the rate of the production of FNDC5.<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_4\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">FNDC5 -IRISIN<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_4\">\n\n\n<ol class=\"wp-block-list\"><li>FNDC5 is produced by exercised muscle<\/li><li>FNDC5 is converted to a hormone, IRISIN<\/li><li>Is cleaved by proteolysis and a 22kDa fragment (IRISIN) is released to the bloodstream<\/li><li>Irisin acts on white adipose tissue and stimulates UCP1 (uncouplingprotein1) expression<\/li><li>It induces a brown-fat-like development<\/li><li>Irisin converts the subcutaneous adipose tissue, stimulating browning and UCP1 expression (UCP1 )<\/li><li>Increase in total body energy expenditure<\/li><li>Decrease the chance of the development of obesity-linked insulin resistance.<\/li><\/ol>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Basic effects of exercise on the metabolism of fatty acids<\/h4><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Gene expression effects of exercise on the metabolism<\/h3><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">PGC1-\u03b1<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">FNDC5 -IRISIN<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>Basic effects of exercise on the metabolism of fatty acids AMPK is activated AMPK phosphorylates and inactivates the Acetyl-CoA carboxylase\u00a0(Synthesis of Malonyl-CoA) Malonyl-Coa level decreases CPT1 inhibition disappears The transport of the fatty acid into the mitochondria and the rate of \u03b2-oxidation is increased AMPK also phosphorylates glycerol-3-phosphate acyltransferase TAG synthesis is inhibited. Gene expression [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":278,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2337","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Effect of exercise on the metabolism of fatty acids &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/effect-of-exercise-on-the-metabolism-of-fatty-acids\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/sports-biochemistry\\\/effect-of-exercise-on-the-metabolism-of-fatty-acids\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/sports-biochemistry\\\/effect-of-exercise-on-the-metabolism-of-fatty-acids\\\/\",\"name\":\"Effect of exercise on the metabolism of fatty acids &#8211; 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