{"id":2336,"date":"2020-09-21T12:18:21","date_gmt":"2020-09-21T10:18:21","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/sports-biochemistry\/physical-activity-induced-regulatory-processes-and-their-beneficial-effects-on-health\/"},"modified":"2020-12-14T14:33:29","modified_gmt":"2020-12-14T12:33:29","slug":"physical-activity-induced-regulatory-processes-and-their-beneficial-effects-on-health","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/physical-activity-induced-regulatory-processes-and-their-beneficial-effects-on-health\/","title":{"rendered":"Physical activity induced regulatory processes and their beneficial effects on health"},"content":{"rendered":"<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Production of AMP during physical activity<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">AMP is produced by the usage of ATP in a simple reaction upon the physical activity or calorie restriction (Figure 1).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-style-default\"><a href=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/ADP.jpg\" target=\"_blank\" title=\"Physical activity induced regulatory processes and their beneficial effects on health\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"313\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/ADP-1024x313.jpg\" alt=\"\" class=\"wp-image-3122\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/ADP-1024x313.jpg 1024w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/ADP-300x92.jpg 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/ADP-768x234.jpg 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/ADP.jpg 1451w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption><strong>Figure 1. Exercise-induced activation of the AMPK<\/strong><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">AMP-activated protein kinase \u2014 AMPK (Figure 2)<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<ul class=\"wp-block-list\"><li>The primary sensor of the energy status of the cell.<\/li><li>Exercise is responsible for the observed increase in muscle glucose uptake.<\/li><li>Heterotrimeric enzyme:<ul><li>\u03b1 \u2014 catalytic site<\/li><li>\u03b2 \u2014 regulatory site<\/li><li>\u03b3 \u2014 regulatory site.<\/li><\/ul><\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"950\" height=\"390\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/AMPK.jpg\" alt=\"\" class=\"wp-image-3124\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/AMPK.jpg 950w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/AMPK-300x123.jpg 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2020\/12\/AMPK-768x315.jpg 768w\" sizes=\"auto, (max-width: 950px) 100vw, 950px\" \/><figcaption><strong>Figure 2. AMPK<\/strong><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">The \u03b3 regulatory subunit<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<ul class=\"wp-block-list\"><li>It has two nucleotide-binding sites.<\/li><li>Able to bind either AMP or ATP.<\/li><li>Predominantly saturated by ATP.<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_4\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Physiological activation of AMPK<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_4\">\n\n\n<ul class=\"wp-block-list\"><li>This occurs in skeletal muscle during exercise.<\/li><li>Phosphorylation of the THR172 on the \u03b1-subunit.<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_5\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">The \u03b2 regulatory subunit<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_5\">\n\n\n<ul class=\"wp-block-list\"><li>Serves as a glycogen sensor.<\/li><li>Glycogen can bind to it.<\/li><li>The activity of the AMPK is decreased by the binding of glycogen.<\/li><\/ul>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Production of AMP during physical activity<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">AMP-activated protein kinase \u2014 AMPK (Figure 2)<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">The \u03b3 regulatory subunit<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Physiological activation of AMPK<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">The \u03b2 regulatory subunit<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>Production of AMP during physical activity AMP is produced by the usage of ATP in a simple reaction upon the physical activity or calorie restriction (Figure 1). AMP-activated protein kinase \u2014 AMPK (Figure 2) The primary sensor of the energy status of the cell. Exercise is responsible for the observed increase in muscle glucose uptake. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":278,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2336","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Physical activity induced regulatory processes and their beneficial effects on health &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-tissues\/sports-biochemistry\/physical-activity-induced-regulatory-processes-and-their-beneficial-effects-on-health\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/sports-biochemistry\\\/physical-activity-induced-regulatory-processes-and-their-beneficial-effects-on-health\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-tissues\\\/sports-biochemistry\\\/physical-activity-induced-regulatory-processes-and-their-beneficial-effects-on-health\\\/\",\"name\":\"Physical activity induced regulatory processes and their beneficial effects on health &#8211; 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