{"id":2302,"date":"2020-09-19T22:36:38","date_gmt":"2020-09-19T20:36:38","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/molecular-biology\/enzymes\/"},"modified":"2021-02-22T11:16:10","modified_gmt":"2021-02-22T10:16:10","slug":"enzymes","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/molecular-biology\/enzymes\/","title":{"rendered":"Enzymes I."},"content":{"rendered":"\n

Enzymes<\/strong>:<\/p>\n\n\n\n
  1. proteins that are biological catalysts<\/li>
  2. accelerate chemical or biochemical reactions<\/li>
  3. molecules at which the enzymes act are called substrates<\/li>
  4. enzymes convert substrates into products <\/div><\/li><\/ol>\n\n\n\n

    Enzymes – Proteins<\/h2>\n<\/span>\n\n\n

    All the enzymes are proteins, which means:<\/p>\n\n\n\n

    1. composed of amino acids<\/li>
    2. have protein-like features<\/li>
    3. can be denaturated<\/li>
    4. have primary\/secondary\/tertiary\/quaternary structures<\/li><\/ol>\n\n\n\n
      \"\"<\/a>
      Figure 1. Enzymes <\/strong><\/figcaption><\/figure>\n\n\n<\/span>\n

      Cofactors<\/h2>\n<\/span>\n\n\n

      Cofactors are non-protein molecules. They help the enzyme activity. They can be classified into:<\/p>\n\n\n\n

      1. inorganic (metal ions)<\/li>
      2. organic compounds (flavin and heme)<\/li><\/ol>\n\n\n<\/span>\n

        PLP- Vitamin B6 derivative<\/h2>\n<\/span>\n\n\n

        PLP- called Pyridoxal phosphate which is a Vitamin B6 (Pyridoxine) derivative. It has different side chains by which it serves as a prosthetic group for the enzymes like GPT\/GOT. (Figure 2-3)<\/p>\n\n\n\n

        \"\"<\/a>
        Figure 2. Cofactors<\/strong> and prosthetic groups<\/figcaption><\/figure>\n\n\n\n
        \"\"<\/a>
        Figure 3. PLP in action<\/strong><\/figcaption><\/figure>\n\n\n<\/span>\n

        ENZYME SPECIFICITY; THE ACTIVE SITE<\/h2>\n<\/span>\n\n\n

        The ACtive site is where substrates are bound by multiple weak attractions The specificity of binding depends on the precisely defined arrangement of atoms in an active site (Figure 4.)<\/p>\n\n\n\n

        \"\"<\/a>
        Figure 4. Active site and the lock key model<\/strong><\/figcaption><\/figure>\n<\/span>

        Enzymes – Proteins<\/h2>

        Cofactors<\/h2>

        PLP- Vitamin B6 derivative<\/h2>

        ENZYME SPECIFICITY; THE ACTIVE SITE<\/h2><\/div>","protected":false},"excerpt":{"rendered":"

        Enzymes – Proteins All the enzymes are proteins, which means: composed of amino acids have protein-like features can be denaturated have primary\/secondary\/tertiary\/quaternary structures Cofactors Cofactors are non-protein molecules. They help the enzyme activity. They can be classified into: inorganic (metal ions) organic compounds (flavin and heme) PLP- Vitamin B6 derivative PLP- called Pyridoxal phosphate which […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":284,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2302","page","type-page","status-publish","hentry"],"yoast_head":"\nEnzymes I. – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/molecular-biology\/enzymes\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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