{"id":1939,"date":"2020-08-19T13:30:17","date_gmt":"2020-08-19T13:30:17","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/succinyl-coa-pathway\/"},"modified":"2021-12-15T10:23:48","modified_gmt":"2021-12-15T08:23:48","slug":"succinyl-coa-pathway","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/succinyl-coa-pathway\/","title":{"rendered":"Succinyl-CoA pathway"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><div class=\"intro\">The succinyl-CoA pathway is responsible for the degradation of essential amino acids, resulting in the formation of succinyl-CoA, which can then be used in the TCA cycle.<\/div><\/p>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Description<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">Succinyl-CoA pathway degrades the following amino acids:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Methionine<\/li><li>Threonine<\/li><li>Valine<\/li><li>Isoleucine<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">These amino acids have glucogenic features, but their degradation occurs through a lipid-like degradation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The end result is succinyl-CoA, which can then be used in the TCA cycle.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\"><\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Typical reactions of the Succinyl-CoA pathway<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">The propionyl-CoA to succinyl-CoA conversion is also part of the degradation of odd-numbered chain fatty acids. This pathway occurs in the mitochondrion (<strong>Figure 1<\/strong>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are 2 big metabolic processes are represented there:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>DECARBOXYLATION (VAL\/ILE-PROPIONYL-COA)<\/li><li>CARBOXYLATION (PROPIONYL-COA \u2013 SUCCINYL-COA)<\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Enzymes and cofactors which are required for the processes:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><strong>DECARBOXYLATION (VAL\/ILE-PROPIONYL-COA)<\/strong><ul><li>BCKDC (Branched-Chain Alpha-ketoacid decarboxylase),&nbsp; cofactor: TPP\/FAD\/NAD\/Lipoamide\/SH-CoA<\/li><\/ul><\/li><li><strong>CARBOXYLATION IN TWO STEPS (PROPIONYL-COA \u2013 SUCCINYL-COA)<\/strong><ul><li>PROPIONYL CARBOXYLASE, cofactor: BIOTIN<\/li><li>METHYLMALONYL-COA MUTASE, cofactor: deoxyadenosyl-B12<\/li><\/ul><\/li><\/ol>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA26-4.png\" target=\"_blank\" title=\"Succinyl-CoA pathway\"><img loading=\"lazy\" decoding=\"async\" width=\"911\" height=\"1024\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA26-4-911x1024.png\" alt=\"\" class=\"wp-image-9226\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA26-4-911x1024.png 911w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA26-4-267x300.png 267w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA26-4-768x863.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA26-4-1367x1536.png 1367w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA26-4.png 1767w\" sizes=\"auto, (max-width: 911px) 100vw, 911px\" \/><\/a><\/figure>\n<\/div>\n<\/div>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">References<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<p class=\"wp-block-paragraph\">S<span style=\"font-size: revert; color: initial;\">nider MDS. Devlin\u2019s <strong>Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley &amp; Sons, Incorporated, 2020; 2019.<\/span>  <\/p>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Description<\/h3><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Typical reactions of the Succinyl-CoA pathway<\/h4><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">References<\/h3><\/div>","protected":false},"excerpt":{"rendered":"<p>Description Succinyl-CoA pathway degrades the following amino acids: Methionine Threonine Valine Isoleucine These amino acids have glucogenic features, but their degradation occurs through a lipid-like degradation. The end result is succinyl-CoA, which can then be used in the TCA cycle. Typical reactions of the Succinyl-CoA pathway The propionyl-CoA to succinyl-CoA conversion is also part of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1714,"menu_order":25,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1939","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Succinyl-CoA pathway &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/succinyl-coa-pathway\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/succinyl-coa-pathway\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/succinyl-coa-pathway\\\/\",\"name\":\"Succinyl-CoA pathway &#8211; 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