{"id":1931,"date":"2020-08-19T13:30:17","date_gmt":"2020-08-19T13:30:17","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/decarboxylation-reactions\/"},"modified":"2021-12-09T06:16:54","modified_gmt":"2021-12-09T04:16:54","slug":"decarboxylation-reactions","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/decarboxylation-reactions\/","title":{"rendered":"Decarboxylation Reactions"},"content":{"rendered":"\n

In the case of the removal of the carboxyl group also can occur in an oxidative<\/strong> and non-oxidative<\/strong> manner. <\/div><\/p>\n\n\n\n

Oxidative decarboxylation<\/h3>\n<\/span>\n\n\n

The enzyme which is capable of removing the carboxyl group in an oxidative way: \u03b1-keto acid dehydrogenase enzyme complex (KDC)<\/strong>. The end product<\/p>\n\n\n\n

Three mitochondrial complexes belong to this family:<\/p>\n\n\n\n

  1. pyruvate dehydrogenase complex (PDC),<\/strong><\/li>
  2. \u03b1-KG dehydrogenase complex, and<\/strong><\/li>
  3. branched-chain \u03b1-keto acid dehydrogenase complex (BCKDC).<\/strong><\/li><\/ol>\n\n\n\n
    \n
    \n

    The end product of the oxidative decarboxylation is acyl-CoA molecules:<\/p>\n\n\n\n

    1. acyl-CoA<\/strong><\/li>
    2. propionyl-CoA<\/strong><\/li>
    3. glutaryl-CoA<\/strong><\/li><\/ol>\n\n\n\n
      1. Branched-chain amino acids (VAL, ILE, LEU) by the BCKDC-mediated reaction to Ayl-CoA.<\/li>
      2. Degradation of MET and THR occurs through an \u03b1-ketobutyrate intermediate that is converted to propionyl-CoA.<\/li>
      3. The degradation of TRP and LYS occurs through \u03b1-ketoadipate to glutaryl-CoA.<\/li><\/ol>\n<\/div>\n\n\n\n
        \n
        \"\"<\/a>
        Figure 1. BCKDC in action<\/strong><\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n<\/span>\n

        References<\/h2>\n<\/span>\n\n\n

        Snider MDS. Devlin\u2019s Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley & Sons, Incorporated, 2020; 2019.<\/span> <\/p>\n<\/span>

        Oxidative decarboxylation<\/h3>

        References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"

        Oxidative decarboxylation The enzyme which is capable of removing the carboxyl group in an oxidative way: \u03b1-keto acid dehydrogenase enzyme complex (KDC). The end product Three mitochondrial complexes belong to this family: pyruvate dehydrogenase complex (PDC), \u03b1-KG dehydrogenase complex, and branched-chain \u03b1-keto acid dehydrogenase complex (BCKDC). The end product of the oxidative decarboxylation is acyl-CoA molecules: […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1714,"menu_order":17,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1931","page","type-page","status-publish","hentry"],"yoast_head":"\nDecarboxylation Reactions – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/decarboxylation-reactions\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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