{"id":1930,"date":"2020-08-19T13:30:17","date_gmt":"2020-08-19T13:30:17","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/"},"modified":"2021-12-08T21:51:49","modified_gmt":"2021-12-08T19:51:49","slug":"intercellular-glutamine-cycle","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/","title":{"rendered":"Intercellular Glutamine Cycle"},"content":{"rendered":"\n

The intercellular glutamine cycle occurs in the liver around the central vein and the periportal cells. The importance of the reactions and the period is the balance between the alkaline and basic blood pH by the presence of excess ammonia or amino acids <\/div><\/p>\n\n\n\n
\n
\n

The cells in this periportal area contain glutaminase<\/strong> and are in contact with blood coming from skeletal muscle.<\/p>\n\n\n\n

The cells of the perivenous area represent 5% of parenchymal cells and contain glutamine synthetase<\/strong>.<\/p>\n\n\n\n

The intercellular glutamine cycle makes it possible to control the flux of ammonia to urea or to glutamine<\/strong>, and the excretion of ammonia by the kidney under different pH conditions.<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/a>
Figure 1. Intracellular glutamine cycle<\/strong><\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n

The flux of compounds in the intercellular glutamine cycle (Figure 1<\/strong>) are the following:<\/p>\n\n\n\n

  • in\u00a0acidosis, the liver produces glutamine,<\/strong>\u00a0while<\/li>
  • in\u00a0alkalosis, the liver is a net glutamine consumer<\/strong>.<\/li><\/ul>\n\n\n\n

    References<\/h2>\n<\/span>\n\n\n

    Snider MDS. Devlin\u2019s Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley & Sons, Incorporated, 2020; 2019.<\/span> <\/p>\n<\/span>

    References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"

    The cells in this periportal area contain glutaminase and are in contact with blood coming from skeletal muscle. The cells of the perivenous area represent 5% of parenchymal cells and contain glutamine synthetase. The intercellular glutamine cycle makes it possible to control the flux of ammonia to urea or to glutamine, and the excretion of ammonia by the […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1714,"menu_order":16,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1930","page","type-page","status-publish","hentry"],"yoast_head":"\nIntercellular Glutamine Cycle – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/\",\"name\":\"Intercellular Glutamine Cycle – Meddists\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/meddists.com\\\/learn\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/AA14-1024x778.png\",\"datePublished\":\"2020-08-19T13:30:17+00:00\",\"dateModified\":\"2021-12-08T19:51:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/#primaryimage\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/AA14.png\",\"contentUrl\":\"https:\\\/\\\/meddists.com\\\/learn\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/AA14.png\",\"width\":3244,\"height\":2465},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/intercellular-glutamine-cycle\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\\\/\\\/meddists.com\\\/learn\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pre-clinical\",\"item\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Biochemistry\",\"item\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Biochemistry of the metabolism\",\"item\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Amino acid metabolism\",\"item\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/amino-acid-metabolism\\\/\"},{\"@type\":\"ListItem\",\"position\":6,\"name\":\"Intercellular Glutamine Cycle\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/#website\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/\",\"name\":\"Meddists\",\"description\":\"Let's Get Studying\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/meddists.com\\\/learn\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Intercellular Glutamine Cycle – Meddists","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/","url":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/","name":"Intercellular Glutamine Cycle – Meddists","isPartOf":{"@id":"https:\/\/meddists.com\/learn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/#primaryimage"},"image":{"@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/#primaryimage"},"thumbnailUrl":"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA14-1024x778.png","datePublished":"2020-08-19T13:30:17+00:00","dateModified":"2021-12-08T19:51:49+00:00","breadcrumb":{"@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/#primaryimage","url":"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA14.png","contentUrl":"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA14.png","width":3244,"height":2465},{"@type":"BreadcrumbList","@id":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/intercellular-glutamine-cycle\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"http:\/\/meddists.com\/learn\/"},{"@type":"ListItem","position":2,"name":"Pre-clinical","item":"https:\/\/meddists.com\/learn\/pre-clinical\/"},{"@type":"ListItem","position":3,"name":"Biochemistry","item":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/"},{"@type":"ListItem","position":4,"name":"Biochemistry of the metabolism","item":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/"},{"@type":"ListItem","position":5,"name":"Amino acid metabolism","item":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/"},{"@type":"ListItem","position":6,"name":"Intercellular Glutamine Cycle"}]},{"@type":"WebSite","@id":"https:\/\/meddists.com\/learn\/#website","url":"https:\/\/meddists.com\/learn\/","name":"Meddists","description":"Let's Get Studying","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/meddists.com\/learn\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/1930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/comments?post=1930"}],"version-history":[{"count":6,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/1930\/revisions"}],"predecessor-version":[{"id":8954,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/1930\/revisions\/8954"}],"up":[{"embeddable":true,"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/pages\/1714"}],"wp:attachment":[{"href":"https:\/\/meddists.com\/learn\/wp-json\/wp\/v2\/media?parent=1930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}