{"id":1920,"date":"2020-08-19T13:30:16","date_gmt":"2020-08-19T13:30:16","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/amino-acid-transport-group-specific-transporters\/"},"modified":"2021-12-07T20:58:30","modified_gmt":"2021-12-07T18:58:30","slug":"amino-acid-transport-group-specific-transporters","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/amino-acid-metabolism\/amino-acid-transport-group-specific-transporters\/","title":{"rendered":"Amino Acid Transport \u2013 Group-Specific Transporters"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><div class=\"intro\"> In mammals, amino acid transporters are grouped into big solute carrier (SLC) families.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>SLC carry out\u00a0<strong>carrier-mediated<\/strong>,\u00a0<strong>energy-dependent<\/strong>\u00a0transport<\/li><li>In the case of the Na<sup>+<\/sup>-cotransporters, the required energy is utilized to pump out the ion <\/div><\/li><\/ul>\n\n\n\n<div class=\"wp-block-image is-style-default\"><figure class=\"alignright size-large is-resized\"><a href=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA4.png\" target=\"_blank\" title=\"Amino Acid Transport \u2013 Group-Specific Transporters\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA4-1024x943.png\" alt=\"\" class=\"wp-image-8841\" width=\"256\" height=\"236\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA4-1024x943.png 1024w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA4-300x276.png 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA4-768x707.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/12\/AA4.png 1522w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><\/a><figcaption><strong>Figure 1.<\/strong> Group transport of the essential amino acids via LAT1 transporter<\/figcaption><\/figure><\/div>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">LAT1 <\/h2>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">One important group-specific transporter is&nbsp;<strong>LAT1&nbsp;<\/strong>which&nbsp;<strong>transports essential&nbsp;or conditionally essential aromatic and large hydrophobic amino acids<\/strong>&nbsp;in a Na<sup>+<\/sup>-independent way (Figure 1):<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is important to see that :<\/p>\n\n\n\n<ul class=\"has-background wp-block-list\" style=\"background-color:#dffcf0\"><li>the LAT1 transporter&#8217;s first passenger is the PHE<\/li><li>PHE can saturate the LAT1 , followed the blockage of the other amino acid uptake<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Clinical correlations<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<ul class=\"wp-block-list\"><li>As LAT1 transports several amino acids into the cells, in\u00a0<strong>PKU<\/strong>\u00a0(phenylketonuria), an\u00a0<strong>elevated Phe level blocks the transport of the other amino acids<\/strong>\u00a0causing the deficiency of the other essential amino acids transported by LAT1 in the (neural) cells<\/li><li>In\u00a0<em><strong>Hartnup disease,<\/strong>\u00a0<\/em>there is a deficiency of a transporter, leading to neutral aminoaciduria due to the lack of luminal absorption and kidney resorption of these critical amino acids<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">References<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<p class=\"wp-block-paragraph\">S<span style=\"font-size: revert; color: initial;\">nider MDS. Devlin\u2019s <strong>Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley &amp; Sons, Incorporated, 2020; 2019.<\/span>  <\/p>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">LAT1 <\/h2><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">Clinical correlations<\/h2><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"<p>LAT1 One important group-specific transporter is&nbsp;LAT1&nbsp;which&nbsp;transports essential&nbsp;or conditionally essential aromatic and large hydrophobic amino acids&nbsp;in a Na+-independent way (Figure 1): It is important to see that : the LAT1 transporter&#8217;s first passenger is the PHE PHE can saturate the LAT1 , followed the blockage of the other amino acid uptake Clinical correlations As LAT1 transports [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1714,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1920","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Amino Acid Transport \u2013 Group-Specific Transporters &#8211; 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