{"id":1854,"date":"2020-08-18T13:29:51","date_gmt":"2020-08-18T13:29:51","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/metabolic-relationships-between-the-major-tissues-in-the-well-fed-state\/"},"modified":"2021-11-19T20:46:01","modified_gmt":"2021-11-19T18:46:01","slug":"metabolic-relationships-between-the-major-tissues-in-the-well-fed-state","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/metabolic-relationships-between-the-major-tissues-in-the-well-fed-state\/","title":{"rendered":"Metabolic Relationships Between the Major Tissues in the Well-Fed State"},"content":{"rendered":"<span class=\"block-heading\" id=\"header_1\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Dietary glucose<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ul class=\"wp-block-list\"><li>can be converted into glycogen by glycogenesis,<\/li><li>converted into pyruvate and lactate by glycolysis,<\/li><li>or used in the pentose phosphate pathway for the generation of NADPH for synthetic processes in the liver.<\/li><\/ul>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large is-resized\"><a href=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/Lipid26.png\" target=\"_blank\" title=\"Metabolic Relationships Between the Major Tissues in the Well-Fed State\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/Lipid26-799x1024.png\" alt=\"\" class=\"wp-image-8197\" width=\"200\" height=\"256\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/Lipid26-799x1024.png 799w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/Lipid26-234x300.png 234w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/Lipid26-768x985.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/Lipid26-1198x1536.png 1198w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/Lipid26.png 1248w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/figure><\/div>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Pyruvate<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">It can be oxidised to acetyl CoA, which can subsequently be converted into triacylglycerol or oxidised to CO<sub>2<\/sub>\u00a0and water by the TCA cycle. A high amount of the dietary glucose goes through the liver to reach other organs, including the brain, which is almost entirely dependent on<strong> glucose for ATP generation<\/strong>, red blood cells and the renal medulla, which can only carry out glycolysis, and adipose tissue, which mainly converts it into the glycerol moiety of triacylglycerol. Muscle also uses glucose, converting it to glycogen or utilising it in glycolysis and the TCA cycle.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Lactate and pyruvate<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/LACTATE-SHUTTLE-_EXERCISE-1024x402.png\" alt=\"\" class=\"wp-image-8199\" width=\"512\" height=\"201\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/LACTATE-SHUTTLE-_EXERCISE-1024x402.png 1024w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/LACTATE-SHUTTLE-_EXERCISE-300x118.png 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/LACTATE-SHUTTLE-_EXERCISE-768x302.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/LACTATE-SHUTTLE-_EXERCISE-1536x603.png 1536w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/LACTATE-SHUTTLE-_EXERCISE-2048x804.png 2048w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/11\/LACTATE-SHUTTLE-_EXERCISE.png 1600w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Generated by glycolysis in peripheral tissues are taken up by the liver and oxidised to CO<sub>2<\/sub>\u00a0or converted to triacylglycerol.<\/p>\n\n\n\n<p class=\"has-light-green-cyan-background-color has-background wp-block-paragraph\"><strong>In the well-fed state, the liver utilises glucose and does not engage in gluconeogenesis<\/strong>. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Thus, the Cori cycle, conversion of glucose to lactate in peripheral tissues followed by conversion of lactate to glucose in the liver, is inhibited in this state.<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_4\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Dietary triacylglycerol<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_4\">\n\n\n<p class=\"wp-block-paragraph\">Gets to the bloodstream as chylomicrons, which in turn are acted upon by lipoprotein lipase connected to the surface of endothelial cells in the lumen of the capillaries of various tissues, but particularly adipose tissue.<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_5\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">References<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_5\">\n\n\n<p class=\"wp-block-paragraph\">S<span style=\"font-size: revert; color: initial;\">nider MDS. Devlin\u2019s <strong>Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley &amp; Sons, Incorporated, 2020; 2019.<\/span>  <\/p>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Dietary glucose<\/h3><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Pyruvate<\/h3><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Lactate and pyruvate<\/h3><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">Dietary triacylglycerol<\/h3><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"<p>Dietary glucose can be converted into glycogen by glycogenesis, converted into pyruvate and lactate by glycolysis, or used in the pentose phosphate pathway for the generation of NADPH for synthetic processes in the liver. Pyruvate It can be oxidised to acetyl CoA, which can subsequently be converted into triacylglycerol or oxidised to CO2\u00a0and water by [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1712,"menu_order":17,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1854","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Metabolic Relationships Between the Major Tissues in the Well-Fed State &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/metabolic-relationships-between-the-major-tissues-in-the-well-fed-state\/\" \/>\n<meta name=\"twitter:label1\" 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