{"id":1843,"date":"2020-08-18T13:26:45","date_gmt":"2020-08-18T13:26:45","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/synthesis-of-triacyl-glycerols\/"},"modified":"2021-10-31T09:30:54","modified_gmt":"2021-10-31T07:30:54","slug":"synthesis-of-triacyl-glycerols","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/synthesis-of-triacyl-glycerols\/","title":{"rendered":"Synthesis of Triacyl-Glycerols"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><div class=\"intro\"> Most tissues are able to convert fatty acids to triacylglycerol (TGs); however, the\u00a0<strong>liver<\/strong>\u00a0and\u00a0<strong>adipose tissue<\/strong>\u00a0are the major producers of TAGs. <\/div><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><a href=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10.png\" target=\"_blank\" title=\"Synthesis of Triacyl-Glycerols\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10-1024x766.png\" alt=\"\" class=\"wp-image-7939\" width=\"512\" height=\"383\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10-1024x766.png 1024w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10-300x224.png 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10-768x574.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10-1536x1148.png 1536w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10-2048x1531.png 2048w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID10.png 1600w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/a><figcaption><strong>Figure 1. Features of the adipocyte<\/strong><\/figcaption><\/figure><\/div>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Adipose tissue<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\"><strong>Adipose tissue<\/strong>\u00a0is a specialised tissue that is suitable for the\u00a0<strong>synthesis<\/strong>,<strong>\u00a0storage<\/strong>, and\u00a0<strong>hydrolysis of triacylglycerol<\/strong> (TAG). Triacylglycerols are\u00a0<strong>stored in lipid vacuoles<\/strong>\u00a0surrounded by the protein\u00a0called <strong>perilipin<\/strong> (Figure 1).<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Liver<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">Triacylglycerol synthesis in the liver is primarily for the production of\u00a0<strong>plasma lipoproteins<\/strong> (<a href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/cholesterol-metabolism\/\">Cholesterol Metabolism<\/a>).<br>The fatty acids used in this process may come from food,\u00a0 adipose tissue via the blood, or from <em>de novo<\/em> synthesis through the catabolism of glucose.<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Triacylglycerols are synthesised from Fatty Acyl CoAs and Glycerol-3-Phosphate<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<ul class=\"has-background wp-block-list\" style=\"background-color:#d0f6e7\"><li>Triacylglycerols are synthesized in most tissues from\u00a0<strong>glycerol-3-phosphate<\/strong>\u00a0and\u00a0<strong>fatty acyl CoAs<\/strong><\/li><li><strong>Glycerol-3-phosphate is synthesised by the reduction of dihydroxyacetone phosphate<\/strong> (<a href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/shuttles-in-order-to-support-glycolysis\/\">Shuttles to support glycolysis<\/a>)<\/li><li>In the fed state, the dihydroxyacetone phosphate is produced from glucose through glycolysis (<a href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/glycolysis\/\">Glycolysis<\/a>)<\/li><\/ul>\n\n\n<\/span><span class=\"block-heading\" id=\"header_4\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Triacylglycerol synthesis<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_4\">\n\n\n<div id=\"attachment_19170\" class=\"wp-block-image\"><figure class=\"alignleft size-large is-resized\"><a href=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11.png\" target=\"_blank\" title=\"Synthesis of Triacyl-Glycerols\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11-1024x648.png\" alt=\"\" class=\"wp-image-7945\" width=\"512\" height=\"324\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11-1024x648.png 1024w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11-300x190.png 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11-768x486.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11-1536x972.png 1536w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11-2048x1296.png 2048w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/10\/LIPID11.png 1600w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/a><figcaption><strong>Figure 2. TAG synthesis<\/strong><\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The synthesis of triacylglycerols&nbsp;<strong>requires the formation of phosphatidic acid<\/strong>.<\/p>\n\n\n\n<p class=\"has-background wp-block-paragraph\" style=\"background-color:#e6f2fb\">Phosphatidic acid is formed by acylation of glycerol-3-phosphate to form lysophosphatidic and then phosphatidic acid<\/p>\n\n\n\n<p class=\"has-background wp-block-paragraph\" style=\"background-color:#cbefe1\">Phosphatidic acid is utilised for triacylglycerol synthesis by hydrolysis of the phosphate group by phosphatidate phosphatase to yield diacylglycerol, which is then acylated to triacylglycerol (<strong>Figure 2<\/strong>)<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_5\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">References<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_5\">\n\n\n<p class=\"wp-block-paragraph\">S<span style=\"font-size: revert; color: initial;\">nider MDS. Devlin\u2019s <strong>Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley &amp; Sons, Incorporated, 2020; 2019.<\/span>  <\/p>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">Adipose tissue<\/h2><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">Liver<\/h2><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">Triacylglycerols are synthesised from Fatty Acyl CoAs and Glycerol-3-Phosphate<\/h2><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">Triacylglycerol synthesis<\/h2><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"<p>Adipose tissue Adipose tissue\u00a0is a specialised tissue that is suitable for the\u00a0synthesis,\u00a0storage, and\u00a0hydrolysis of triacylglycerol (TAG). Triacylglycerols are\u00a0stored in lipid vacuoles\u00a0surrounded by the protein\u00a0called perilipin (Figure 1). Liver Triacylglycerol synthesis in the liver is primarily for the production of\u00a0plasma lipoproteins (Cholesterol Metabolism).The fatty acids used in this process may come from food,\u00a0 adipose tissue via [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1712,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1843","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Synthesis of Triacyl-Glycerols &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/synthesis-of-triacyl-glycerols\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/lipid-metabolism\\\/synthesis-of-triacyl-glycerols\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/lipid-metabolism\\\/synthesis-of-triacyl-glycerols\\\/\",\"name\":\"Synthesis of Triacyl-Glycerols &#8211; 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