{"id":1840,"date":"2020-08-18T13:26:45","date_gmt":"2020-08-18T13:26:45","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/synthesis-of-fatty-acids-lipogenesis\/"},"modified":"2021-11-24T13:48:00","modified_gmt":"2021-11-24T11:48:00","slug":"synthesis-of-fatty-acids-lipogenesis","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/synthesis-of-fatty-acids-lipogenesis\/","title":{"rendered":"Synthesis of Fatty Acids \u2014 Lipogenesis"},"content":{"rendered":"\n

Lipogenesis means the synthesis of the fatty acids, from basic 2C atoms containing Acetyl-CoA molecules. The basic law of synthesis is the +2C\/-2C<\/strong> <\/div><\/p>\n\n\n\n
\n
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During the fed state, excess amounts of dietary carbohydrates which are not used for energy\/glycogen synthesis will be converted to fatty acids in the liver from Acetyl-CoA. This process requires reducing equivalents<\/strong> (NADPH).<\/p>\n\n\n\n

The synthesis of fatty acids occurs in the cytosol of hepatocytes, using Acetyl-CoA (2C) produced from glucose or other precursors (Figure 1<\/strong>).<\/p>\n\n\n\n

The human body is designed to produce C16 <\/sub>palmitate. <\/p>\n\n\n\n

All other fatty acids are made by modification of this molecule. Fatty acids are synthesised by the following addition of two-carbon units from Acetyl-CoA to the activated carboxyl end of a growing chain by fatty acid synthase<\/strong>.<\/p>\n<\/div>\n\n\n\n

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\"\"<\/a>
Figure 1. Pathway involvement in lipid synthesis<\/strong> <\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n

References<\/h2>\n<\/span>\n\n\n

Snider MDS. Devlin\u2019s Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley & Sons, Incorporated, 2020; 2019.<\/span> <\/p>\n<\/span>

References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"

During the fed state, excess amounts of dietary carbohydrates which are not used for energy\/glycogen synthesis will be converted to fatty acids in the liver from Acetyl-CoA. This process requires reducing equivalents (NADPH). The synthesis of fatty acids occurs in the cytosol of hepatocytes, using Acetyl-CoA (2C) produced from glucose or other precursors (Figure 1). The human […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1712,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1840","page","type-page","status-publish","hentry"],"yoast_head":"\nSynthesis of Fatty Acids \u2014 Lipogenesis – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/lipid-metabolism\/synthesis-of-fatty-acids-lipogenesis\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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