{"id":1725,"date":"2020-08-14T17:32:44","date_gmt":"2020-08-14T17:32:44","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/pentose-phosphate-pathway-regulation\/"},"modified":"2021-09-30T22:55:08","modified_gmt":"2021-09-30T20:55:08","slug":"pentose-phosphate-pathway-regulation","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/pentose-phosphate-pathway-regulation\/","title":{"rendered":"Pentose-phosphate pathway regulation"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><div class=\"intro\"> In the pentose-phosphate pathway, pentoses and NADPH are negative regulators, whereas the NADP<sup>+ and glucose-6-P enhance<\/sup> the pathway<\/div><\/p>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">The roles of pentoses and NADPH<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<ul class=\"wp-block-list\"><li>Pentoses are needed for the synthesis of nucleotides and nucleic acids<\/li><li>NADPH is required for the neutralization of the peroxide form in RBC through the Glutathione system (GSS\/GSSH), since peroxide can damage the RBCs<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The irreversible, binding, speed determining step in the process is\u00a0the <strong>glucose-6-phosphate dehydrogenase act.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Based on the level of the pentoses the regulation is the following (<strong>Figure 1<\/strong>):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>High NADP<sup>+<\/sup> level activates the pathway via glucose-6-phosphate dehydrogenase activation (Figure 1)<\/strong><\/li><li><strong>High pentose and NADPH level inhibit glucose-6-phosphate dehydrogenase (Figure 2)<\/strong><\/li><\/ul>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"812\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg-1024x812.png\" alt=\"\" class=\"wp-image-7160\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg-1024x812.png 1024w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg-300x238.png 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg-768x609.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg-1536x1218.png 1536w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg-2048x1625.png 2048w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg.png 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption><strong>Figure 1. NADP<sup>+<\/sup><\/strong><\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"815\" src=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg2-1024x815.png\" alt=\"\" class=\"wp-image-7161\" srcset=\"https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg2-1024x815.png 1024w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg2-300x239.png 300w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg2-768x611.png 768w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg2-1536x1222.png 1536w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg2-2048x1629.png 2048w, https:\/\/meddists.com\/learn\/wp-content\/uploads\/2021\/09\/PPPreg2.png 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption><strong>Figure 2. NADPH effects<\/strong><\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">References<\/h2>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">S<span style=\"font-size: revert; color: initial;\">nider MDS. Devlin\u2019s <strong>Textbook of Biochemistry with Clinical Correlations<\/strong>, the 8th Edition. John Wiley &amp; Sons, Incorporated, 2020; 2019.<\/span>  <\/p>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">The roles of pentoses and NADPH<\/h2><h2 class=\"wp-block-heading\" class=\"wp-block-heading\">References<\/h2><\/div>","protected":false},"excerpt":{"rendered":"<p>The roles of pentoses and NADPH Pentoses are needed for the synthesis of nucleotides and nucleic acids NADPH is required for the neutralization of the peroxide form in RBC through the Glutathione system (GSS\/GSSH), since peroxide can damage the RBCs The irreversible, binding, speed determining step in the process is\u00a0the glucose-6-phosphate dehydrogenase act. Based on [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1711,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1725","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pentose-phosphate pathway regulation &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/pentose-phosphate-pathway-regulation\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/carbohydrate-metabolism\\\/pentose-phosphate-pathway-regulation\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/biochemistry\\\/biochemistry-of-the-metabolism\\\/carbohydrate-metabolism\\\/pentose-phosphate-pathway-regulation\\\/\",\"name\":\"Pentose-phosphate pathway regulation &#8211; 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