{"id":1718,"date":"2020-08-14T17:32:39","date_gmt":"2020-08-14T17:32:39","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/production-of-acetyl-coa-and-the-pyruvate-dehydrogenase-enzyme-complex\/"},"modified":"2021-09-24T20:31:27","modified_gmt":"2021-09-24T18:31:27","slug":"production-of-acetyl-coa-and-the-pyruvate-dehydrogenase-enzyme-complex","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/biochemistry\/biochemistry-of-the-metabolism\/carbohydrate-metabolism\/production-of-acetyl-coa-and-the-pyruvate-dehydrogenase-enzyme-complex\/","title":{"rendered":"Production of Acetyl-CoA and the PDH"},"content":{"rendered":"\n

Pyruvate dehydrogenase complex works on pyruvate to produce Acetyl-CoA. <\/p>\n\n\n\n

The requirements are: pyruvate, SH-Coa, NAD+<\/sup> <\/p>\n\n\n\n

Cofactors of the complex: E1-TPP, E2-LIPOYL RING, E3-FAD <\/div><\/p>\n\n\n\n

The pyruvate dehydrogenase enzyme complex (PDH)<\/h3>\n<\/span>\n\n\n

The three main components \u2014 fatty acids<\/strong>, amino acids<\/strong>, and carbohydrates<\/strong>, can all be transformed into Acetyl-CoA. <\/p>\n\n\n\n

When glucose is converted into pyruvate the pyruvate dehydrogenase enzyme complex (PDH) <\/strong>will form Acetyl-CoA<\/strong>. The enzyme complex in which three components are found, participating in the production of Acetyl-CoA (Figure 1<\/strong>):<\/p>\n\n\n\n

  1. Pyruvate dehydrogenase (E1)<\/strong><\/li>
  2. Dehydrolipoyl transacetylase (E2)<\/strong><\/li>
  3. Dehydrolipoyl dehydrogenase (E3)<\/strong><\/li><\/ol>\n\n\n\n
    \"\"<\/a>
    Figure 1. PDH complex and its features<\/strong> <\/figcaption><\/figure><\/div>\n\n\n<\/span>\n

    Functions<\/em><\/h4>\n<\/span>\n\n\n