{"id":1449,"date":"2020-08-07T00:11:29","date_gmt":"2020-08-07T00:11:29","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/population-genetics\/"},"modified":"2021-01-31T23:49:59","modified_gmt":"2021-01-31T22:49:59","slug":"population-genetics","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/population-genetics\/","title":{"rendered":"Population Genetics"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><div class=\"intro\">Population genetics is a branch of genetics that studies the genotype and genomic distributions in a population.<\/div> Before we start, let us define two important terms here<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Genotypic frequencies<\/li><li>Allelic frequencies<\/li><\/ol>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Genotypic frequencies<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">This is how much a certain genotype occurs in the population.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For example, let us take the gene &#8216;B&#8217; for black hair. Those with BB and Bb have black hair, those with bb have blonde hair. In a certain population, the following numbers were taken;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Homozygous dominant(BB):&nbsp; 234<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Heterozygous(Bb): 132<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Homozygous recessive(bb): 43<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Total: 409<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The genotypic frequency for BB is 234\/409=0.5721<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The genotypic frequency for Bb is 132\/409=0-3227<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The genotypic frequency for bb is 43\/409=0.1051<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_2\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title2\">Allelic frequencies<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_2\">\n\n\n<p class=\"wp-block-paragraph\">This is how much a certain allele occurs in the population.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We will reference the previous example. If 234 people have genotype BB, it means that each of these people has two copies of the allele &#8216;B&#8217;. Therefore in total, these 234 people have 468 &#8216;B&#8217; alleles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If 132 people have genotype Bb, it means that they each have one copy of &#8216;B&#8217; and another of &#8216;b&#8217;. Therefore in total, they have 132 &#8216;B&#8217; alleles and 132 &#8216;b&#8217; alleles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If 43 people have genotype bb, it means that they each have two copies of &#8216;b&#8217;. Therefore in total, they have 86 &#8216;b&#8217; alleles. In total, there are 468+132+132+86= 818 alleles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The allelic frequency for &#8216;B&#8217; is (468+132)\/818=0.7334<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The allelic frequency for &#8216;b&#8217; is (132+86)\/818=0.2665<\/p>\n\n\n<\/span><span class=\"block-heading\" id=\"header_3\">\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">The Hardy-Weinberg Law<\/h3>\n<\/span><span class=\"block-content\" id=\"contents_3\">\n\n\n<p class=\"wp-block-paragraph\">The Hardy-Weinberg law states that <strong>the allelic and genotypic frequencies will always be constant and equal to one<\/strong> in a population as long as certain requirements are met such as no immigration, no mutations, and a large population with random matings.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As no realistic population can fulfill all these requirements, the Hardy-Weinberg law usually refers to an ideal, virtual population.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to the Hardy-Weinberg law,<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>The sum of the allelic frequencies is equal to one. We use &#8216;p&#8217; to denote the dominant allele and &#8216;q&#8217; to denote the recessive one. Therefore,<strong> p+q=1<\/strong><\/li><li>The sum of the genotypic frequencies is equal to one. We use &#8216;p<sup>2<\/sup>&#8216; to denote homozygous dominant, &#8216;2pq&#8217; to denote heterozygous and &#8216;q<sup>2<\/sup>&#8216; to denote homozygous recessive. Therefore,<strong>&nbsp;p<sup>2<\/sup>+2pq+q<sup>2<\/sup>=1<\/strong><\/li><\/ol>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Genotypic frequencies<\/h4><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Allelic frequencies<\/h4><h3 class=\"wp-block-heading\" class=\"wp-block-heading\">The Hardy-Weinberg Law<\/h3><\/div>","protected":false},"excerpt":{"rendered":"<p>Before we start, let us define two important terms here Genotypic frequencies Allelic frequencies Genotypic frequencies This is how much a certain genotype occurs in the population. For example, let us take the gene &#8216;B&#8217; for black hair. Those with BB and Bb have black hair, those with bb have blonde hair. In a certain [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1343,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1449","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Population Genetics &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/population-genetics\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/medical-genetics\\\/population-genetics\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/medical-genetics\\\/population-genetics\\\/\",\"name\":\"Population Genetics &#8211; 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