{"id":1431,"date":"2020-08-06T23:54:07","date_gmt":"2020-08-06T23:54:07","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/transmission-genetics\/mendelian-genetics-the-monohybrid-cross-and-mendels-first-law\/"},"modified":"2021-10-02T22:32:02","modified_gmt":"2021-10-02T20:32:02","slug":"mendelian-genetics-the-monohybrid-cross-and-mendels-first-law","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/transmission-genetics\/mendelian-genetics-the-monohybrid-cross-and-mendels-first-law\/","title":{"rendered":"Mendelian Genetics: The monohybrid cross and Mendel&#8217;s first law"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><div class=\"intro\">A monohybrid cross occurs when the parents differ in one (phenotypic) trait only.<\/div> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Below I will show the steps and the right way to do a monohybrid cross or any cross at all (you can be asked this in the SCT or exam).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mendel crossed plants with Round seeds with those with Wrinkled seeds. The round trait is the dominant one and the wrinkled is recessive.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>When writing the genotypes<strong>, always use the same letter. Use the capital letter for the dominant and the small letter for the recessive.<\/strong><\/li><li>When writing the gametes<strong>, always write them in circles<\/strong> <em>(we will see the reason for this in a bit)<\/em><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Parental Phenotype:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Round\u00d7Wrinkled<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Parental Genotype:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;RR\u00d7rr<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Parental Gametes:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; \u24c7\u24c7\u00d7\u24e1\u24e1<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"pure-table\"><tbody><tr><td>&nbsp;<\/td><td>\u24c7<\/td><td>\u24c7<\/td><\/tr><tr><td>\u24e1<\/td><td>Rr<\/td><td>Rr<\/td><\/tr><tr><td>\u24e1<\/td><td>Rr<\/td><td>Rr<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">F1(1st generation) genotype: Rr<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">F1 phenotype: Round<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As seen here, all the offspring will have the same genotype(heterozygous) and the same phenotype; round. Remember that the dominant trait(Round) will always be expressed once it is present. This is how Mendel knew which traits were dominant and which were recessive.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Now we will cross the <strong>F1<\/strong> organisms with the same steps as above. The table where I make the cross is known as a <strong>Punnett Square<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Parental(F1) Phenotype:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Round\u00d7Round<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">F2 genotype:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Rr\u00d7Rr<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">F2 gametes:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; \u24c7\u24e1\u00d7\u24c7\u24e1<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"pure-table\"><tbody><tr><td>&nbsp;<\/td><td>\u24c7<\/td><td>\u24e1<\/td><\/tr><tr><td>\u24c7<\/td><td>RR<\/td><td>Rr<\/td><\/tr><tr><td>\u24e1<\/td><td>Rr<\/td><td>rr<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">F2 genotype:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; RR:Rr:rr<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Genotypic ratio:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; 1:2:1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">F2 phenotype:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Round:Wrinkled<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Phenotypic ratio:&nbsp; &nbsp; &nbsp; &nbsp; 3:1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As seen above, this &#8216;3:1&#8217; ratio was observed by Mendel in the<strong> F2<\/strong> generation and this &#8216;3:1&#8217; ratio is characteristic for similar monohybrid crosses that follow Mendelian Genetics. He repeated this experiment more than once and found the same ratios so he made explanations and theories for this that eventually lead to him writing <strong>Mendel&#8217;s first law<\/strong>, also known as <strong>The Law of Segregation.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/03\/MendelCruzamientosMonohibridos.jpg\" target=\"_blank\" title=\"Mendelian Genetics: The monohybrid cross and Mendel's first law\"><img decoding=\"async\" src=\"https:\/\/meddists.com\/wp-content\/uploads\/2020\/03\/MendelCruzamientosMonohibridos.jpg\" alt=\"\" class=\"wp-image-26909\"\/><\/a><figcaption><strong>Visual representation of a monohybrid cross of round and wrinkled pea seeds where the round trait is dominant and the wrinkled is recessive.<\/strong> (Credit: Alejandro Porto; CC BY-SA 3.0)<\/figcaption><\/figure><\/div>\n\n\n<span class=\"block-heading\" id=\"header_1\">\n<h4 class=\"wp-block-heading\" class=\"wp-block-heading\" class=\"title_collection title1\">Law of Segregation<\/h4>\n<\/span><span class=\"block-content\" id=\"contents_1\">\n\n\n<p class=\"wp-block-paragraph\">It states that during gamete formation, when two new cells are formed, the two alleles of a gene will segregate and each of the alleles will go into each of the cells so that each new cell\/gamete has one of the alleles.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This is why when we write the gametes during the cross, we write them in circles, to show that they have been segregated and that one allele goes into one gamete.<\/li><li>When Mendel made this law, the cell cycle had not been discovered yet, but now we know that this &#8216;segregation&#8217; he talked about is what happens in Anaphase I of meiosis. Failure of this &#8216;segregation&#8217; to occur is known as <strong>Non-disjunction. <\/strong><em>Details of the cell cycle and non-disjunction is discussed in the Medical Genetics I: Cell cycle and Cytogenetics courses<\/em>.<\/li><\/ul>\n<\/span><div id=\"the_titles\" style=\"display:none;\"><h4 class=\"wp-block-heading\" class=\"wp-block-heading\">Law of Segregation<\/h4><\/div>","protected":false},"excerpt":{"rendered":"<p>Below I will show the steps and the right way to do a monohybrid cross or any cross at all (you can be asked this in the SCT or exam). Mendel crossed plants with Round seeds with those with Wrinkled seeds. The round trait is the dominant one and the wrinkled is recessive. When writing [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1346,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1431","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mendelian Genetics: The monohybrid cross and Mendel&#039;s first law &#8211; Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/transmission-genetics\/mendelian-genetics-the-monohybrid-cross-and-mendels-first-law\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/medical-genetics\\\/transmission-genetics\\\/mendelian-genetics-the-monohybrid-cross-and-mendels-first-law\\\/\",\"url\":\"https:\\\/\\\/meddists.com\\\/learn\\\/pre-clinical\\\/medical-genetics\\\/transmission-genetics\\\/mendelian-genetics-the-monohybrid-cross-and-mendels-first-law\\\/\",\"name\":\"Mendelian Genetics: The monohybrid cross and Mendel's first law &#8211; 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